Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig13	Tmel0123	COG0737	323	3e-89
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig13	Tmel1207	COG0737	344	8e-96
Adenine deaminase	F	Contig13	Tmel0119	COG1001	45	1e-05
Adenine deaminase	F	Contig13	Tmel0120	COG1001	36	0.005
Adenine deaminase	F	Contig13	Tmel0211	COG1001	38	0.001
Adenine deaminase	F	Contig13	Tmel0500	COG1001	61	1e-10
Adenine deaminase	F	Contig13	Tmel0598	COG1001	89	6e-19
Adenine deaminase	F	Contig13	Tmel0694	COG1001	41	2e-04
Adenine deaminase	F	Contig13	Tmel1566	COG1001	46	7e-06
Adenine deaminase	F	Contig13	Tmel1596	COG1001	45	1e-05
Adenine deaminase	F	Contig13	Tmel1731	COG1001	594	1.0e-171
ADP-ribose pyrophosphatase	F	Contig13	Tmel0555	COG1051	50	7e-08
ADP-ribose pyrophosphatase	F	Contig13	Tmel0623	COG1051	73	1e-14
ADP-ribose pyrophosphatase	F	Contig13	Tmel1891	COG1051	45	4e-06
Aspartate carbamoyltransferase regulatory subunit	F	Contig13	Tmel1193	COG1781	147	2e-36
Cytosine/adenosine deaminase	F	Contig13	Tmel0045	COG0590	66	3e-12
Cytosine/adenosine deaminase	F	Contig13	Tmel1766	COG0590	60	1e-10
Deoxycytidylate deaminase	F	Contig13	Tmel0045	COG2131	68	8e-13
Deoxycytidylate deaminase	F	Contig13	Tmel1766	COG2131	190	4e-50
Deoxynucleoside kinase	F	Contig13	Tmel1365	COG1428	42	3e-05
Deoxyribose-phosphate aldolase	F	Contig13	Tmel0243	COG0274	269	2e-73
dGTP triphosphohydrolase	F	Contig13	Tmel1366	COG0232	43	6e-05
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig13	Tmel0076	COG0537	48	8e-07
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig13	Tmel0312	COG0537	107	2e-25
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig13	Tmel0424	COG0537	40	2e-04
Formyltetrahydrofolate synthetase	F	Contig13	Tmel0304	COG2759	792	0.0
Formyltetrahydrofolate synthetase	F	Contig13	Tmel1276	COG2759	36	0.007
Guanylate kinase	F	Contig13	Tmel0099	COG0194	241	2e-65
Orotate phosphoribosyltransferase homologs	F	Contig13	Tmel0161	COG0856	42	7e-05
Orotate phosphoribosyltransferase homologs	F	Contig13	Tmel0269	COG0856	56	1e-09
Orotate phosphoribosyltransferase homologs	F	Contig13	Tmel0389	COG0856	41	1e-04
Orotate phosphoribosyltransferase homologs	F	Contig13	Tmel1418	COG0856	37	7e-04
Orotate phosphoribosyltransferase homologs	F	Contig13	Tmel1842	COG0856	35	0.002
Predicted alternative thymidylate synthase	F	Contig13	Tmel1909	COG1351	187	7e-49
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig13	Tmel0974	COG1936	34	0.008
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig13	Tmel1373	COG1936	44	2e-05
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig13	Tmel1845	COG1936	44	5e-06

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig13	Tmel1243	COG0015	440	1.0e-124
Adenylosuccinate lyase	F	Contig13	Tmel1360	COG0015	86	6e-18
Adenylosuccinate synthase	F	Contig13	Tmel0313	COG0104	402	1.0e-113
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig13	Tmel0387	COG0138	274	5e-75
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig13	Tmel1545	COG0138	268	2e-73
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig13	Tmel0236	COG0299	83	2e-17
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig13	Tmel0388	COG0299	211	3e-56
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig13	Tmel0510	COG0299	104	5e-24
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Tmel0386	COG0027	35	0.008
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Tmel0389	COG0034	489	1.0e-139
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Tmel0471	COG0034	138	1e-33
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Tmel0508	COG0034	75	1e-14
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Tmel0718	COG0518	212	4e-56
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Tmel0784	COG0518	47	3e-06
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Tmel0858	COG0518	38	0.001
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Tmel1235	COG0518	34	0.008
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Tmel1858	COG0518	38	6e-04
GMP synthase PP-ATPase domain/subunit	F	Contig13	Tmel0207	COG0519	46	5e-06
GMP synthase PP-ATPase domain/subunit	F	Contig13	Tmel0718	COG0519	495	1.0e-141
GMP synthase PP-ATPase domain/subunit	F	Contig13	Tmel1404	COG0519	39	0.001
GMP synthase PP-ATPase domain/subunit	F	Contig13	Tmel1605	COG0519	47	1e-06
IMP dehydrogenase/GMP reductase	F	Contig13	Tmel1578	COG0516	149	4e-37
Phosphoribosylamine-glycine ligase	F	Contig13	Tmel0081	COG0151	47	2e-06
Phosphoribosylamine-glycine ligase	F	Contig13	Tmel0386	COG0151	362	1.0e-101
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig13	Tmel0385	COG0150	240	1e-64
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig13	Tmel1236	COG0150	63	9e-11
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Tmel0081	COG0026	43	3e-05
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Tmel0386	COG0026	54	2e-08
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Tmel0486	COG0026	53	3e-08
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig13	Tmel1233	COG0152	215	2e-57
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig13	Tmel1232	COG0041	189	7e-50
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig13	Tmel0784	COG0047	40	5e-04
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig13	Tmel0858	COG0047	36	0.006
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig13	Tmel1235	COG0047	262	2e-71
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	Contig13	Tmel1234	COG1828	70	3e-14
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig13	Tmel1236	COG0046	554	1.0e-159
Phosphoribosylpyrophosphate synthetase	F	Contig13	Tmel0161	COG0462	410	1.0e-116
Phosphoribosylpyrophosphate synthetase	F	Contig13	Tmel0367	COG0462	44	4e-05
Phosphoribosylpyrophosphate synthetase	F	Contig13	Tmel0389	COG0462	44	2e-05
Phosphoribosylpyrophosphate synthetase	F	Contig13	Tmel1418	COG0462	36	0.002
Phosphoribosylpyrophosphate synthetase	F	Contig13	Tmel1842	COG0462	34	0.005

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Tmel0269	COG0503	66	2e-12
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Tmel0389	COG0503	38	0.001
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Tmel1842	COG0503	169	1e-43
Formyltetrahydrofolate hydrolase	F	Contig13	Tmel0236	COG0788	57	1e-09
Formyltetrahydrofolate hydrolase	F	Contig13	Tmel0388	COG0788	112	2e-26
Formyltetrahydrofolate hydrolase	F	Contig13	Tmel0510	COG0788	61	9e-11
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Tmel0161	COG0634	37	0.002
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Tmel0269	COG0634	37	0.001
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Tmel0389	COG0634	39	0.001
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Tmel1418	COG0634	52	2e-08
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Tmel1560	COG0634	195	1e-51
Purine nucleoside phosphorylase	F	Contig13	Tmel0852	COG0005	260	9e-71
Purine nucleoside phosphorylase	F	Contig13	Tmel1526	COG0005	244	6e-66

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig13	Tmel0430	COG0563	33	0.008
Adenylate kinase and related kinase	F	Contig13	Tmel0974	COG0563	184	3e-48
Adenylate kinase and related kinase	F	Contig13	Tmel1622	COG0563	49	3e-07
Aspartate carbamoyltransferase catalytic chain	F	Contig13	Tmel0118	COG0540	151	6e-38
Aspartate carbamoyltransferase catalytic chain	F	Contig13	Tmel1193	COG0540	262	6e-71
Aspartate carbamoyltransferase catalytic chain	F	Contig13	Tmel1814	COG0540	169	3e-43
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Tmel0081	COG0458	55	8e-09
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Tmel0386	COG0458	37	0.003
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Tmel0418	COG0458	35	0.007
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Tmel0486	COG0458	42	9e-05
Carbamoylphosphate synthase small subunit	F	Contig13	Tmel0718	COG0505	77	3e-15
Carbamoylphosphate synthase small subunit	F	Contig13	Tmel0784	COG0505	47	4e-06
CTP synthase (UTP-ammonia lyase)	F	Contig13	Tmel0784	COG0504	721	0.0
Cytidylate kinase	F	Contig13	Tmel0167	COG1102	33	0.008
Cytidylate kinase	F	Contig13	Tmel0974	COG1102	52	4e-08
Cytidylate kinase	F	Contig13	Tmel0974	COG0283	43	2e-05
Cytidylate kinase	F	Contig13	Tmel1373	COG1102	36	0.003
Cytidylate kinase	F	Contig13	Tmel1622	COG1102	70	2e-13
Cytidylate kinase	F	Contig13	Tmel1622	COG0283	250	8e-68
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0119	COG0044	240	2e-64
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0120	COG0044	39	6e-04
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0211	COG0044	41	1e-04
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0265	COG0044	189	2e-49
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0500	COG0044	82	8e-17
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel0598	COG0044	65	8e-12
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel1566	COG0044	54	2e-08
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel1596	COG0044	38	0.001
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel1728	COG0044	48	1e-06
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Tmel1731	COG0044	53	6e-08
Dihydroorotase	F	Contig13	Tmel0265	COG0418	39	4e-04
Dihydroorotate dehydrogenase	F	Contig13	Tmel0121	COG0167	181	7e-47
Dihydroorotate dehydrogenase	F	Contig13	Tmel0243	COG0167	38	0.001
Dihydroorotate dehydrogenase	F	Contig13	Tmel0267	COG0167	181	6e-47
Dihydroorotate dehydrogenase	F	Contig13	Tmel0374	COG0167	35	0.006
Dihydroorotate dehydrogenase	F	Contig13	Tmel1055	COG0167	43	3e-05
Dihydroorotate dehydrogenase	F	Contig13	Tmel1578	COG0167	40	5e-04
Dihydroorotate dehydrogenase	F	Contig13	Tmel1859	COG0167	34	0.009
Orotate phosphoribosyltransferase	F	Contig13	Tmel0161	COG0461	46	4e-06
Orotate phosphoribosyltransferase	F	Contig13	Tmel0269	COG0461	132	1e-32
Orotate phosphoribosyltransferase	F	Contig13	Tmel1842	COG0461	49	1e-07
Orotidine-5'-phosphate decarboxylase	F	Contig13	Tmel0268	COG0284	131	3e-32
Uridylate kinase	F	Contig13	Tmel0208	COG0528	37	0.002
Uridylate kinase	F	Contig13	Tmel0482	COG0528	250	6e-68
Uridylate kinase	F	Contig13	Tmel1878	COG0528	68	2e-12

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig13	Tmel1418	COG2065	200	7e-53
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig13	Tmel1560	COG2065	37	7e-04

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytidine deaminase	F	Contig13	Tmel1508	COG0295	172	7e-45
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0119	COG0402	67	3e-12
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0120	COG0402	182	5e-47
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0211	COG0402	89	7e-19
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0500	COG0402	80	3e-16
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0598	COG0402	80	2e-16
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel0694	COG0402	39	8e-04
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel1346	COG0402	35	0.010
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel1566	COG0402	278	7e-76
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel1596	COG0402	54	2e-08
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel1728	COG0402	278	5e-76
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Tmel1731	COG0402	54	3e-08
Nucleoside phosphorylase	F	Contig13	Tmel0485	COG0775	103	1e-23
Nucleoside phosphorylase	F	Contig13	Tmel0852	COG0775	42	4e-05
Nucleoside phosphorylase	F	Contig13	Tmel1526	COG0775	35	0.006
Purine-nucleoside phosphorylase	F	Contig13	Tmel0485	COG0813	52	3e-08
Purine-nucleoside phosphorylase	F	Contig13	Tmel0852	COG0813	42	4e-05
Thymidine kinase	F	Contig13	Tmel1206	COG1435	183	7e-48
Thymidine phosphorylase	F	Contig13	Tmel1840	COG0213	498	1.0e-142
Uracil phosphoribosyltransferase	F	Contig13	Tmel1394	COG0035	278	2e-76
Uracil phosphoribosyltransferase	F	Contig13	Tmel1418	COG0035	35	0.003
Uridine kinase	F	Contig13	Tmel1365	COG0572	220	5e-59
Uridine kinase	F	Contig13	Tmel1622	COG0572	44	7e-06
Uridine kinase	F	Contig13	Tmel1763	COG0572	164	1e-41

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized enzyme of thiazole biosynthesis	F	Contig13	Tmel1859	COG2022	50	3e-07

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Nucleoside diphosphate kinase	F	Contig13	Tmel0381	COG0105	186	6e-49
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig13	Tmel0604	COG1328	417	1.0e-117
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig13	Tmel1376	COG1328	38	2e-04
Ribonucleotide reductase alpha subunit	F	Contig13	Tmel0606	COG0209	388	1.0e-109
Thymidylate kinase	F	Contig13	Tmel0099	COG0125	35	0.003
Thymidylate kinase	F	Contig13	Tmel0927	COG0125	203	9e-54
Thymidylate kinase	F	Contig13	Tmel0974	COG0125	42	3e-05
Thymidylate kinase	F	Contig13	Tmel1310	COG0125	36	0.002
Thymidylate kinase	F	Contig13	Tmel1806	COG0125	37	0.003

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uridine phosphorylase	F	Contig13	Tmel0485	COG2820	34	0.007
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig13	Tmel1320	COG4630	92	1e-20
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig13	Tmel1322	COG4630	111	6e-26
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig13	Tmel1323	COG4630	137	4e-34
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig13	Tmel1319	COG4631	258	1e-69
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig13	Tmel1730	COG4631	431	1.0e-122
Xanthine/uracil permease	F	Contig13	Tmel0066	COG2233	298	4e-82
Xanthine/uracil permease	F	Contig13	Tmel0441	COG2233	46	5e-06
Xanthosine triphosphate pyrophosphatase	F	Contig13	Tmel0184	COG0127	201	3e-53

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