Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	BX548020	SYNW2390	COG0737	123	4e-29
Adenine deaminase	F	BX548020	SYNW2449	COG1001	46	5e-06
Adenosine deaminase	F	BX548020	SYNW1592	COG2169	42	4e-05
ADP-ribose pyrophosphatase	F	BX548020	SYNW0115	COG1051	64	1e-11
ADP-ribose pyrophosphatase	F	BX548020	SYNW0218	COG1051	38	3e-04
ADP-ribose pyrophosphatase	F	BX548020	SYNW1334	COG1051	45	1e-06
ATP adenylyltransferase (5' 5'''-P-1 P-4-tetraphosphate phosphorylase II)	F	BX548020	SYNW1233	COG4360	140	1e-34
Cytosine/adenosine deaminase	F	BX548020	SYNW1076	COG0590	138	2e-34
Cytosine/adenosine deaminase	F	BX548020	SYNW1590	COG0590	73	4e-14
Deoxycytidylate deaminase	F	BX548020	SYNW1076	COG2131	40	8e-05
Deoxycytidylate deaminase	F	BX548020	SYNW1590	COG2131	56	4e-09
Deoxynucleoside kinase	F	BX548020	SYNW2027	COG1428	37	0.003
Deoxynucleoside kinase	F	BX548020	SYNW2443	COG1428	36	0.003
Deoxyribose-phosphate aldolase	F	BX548020	SYNW0666	COG0274	135	3e-33
dGTP triphosphohydrolase	F	BX548020	SYNW1969	COG0232	45	8e-06
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	BX548020	SYNW0328	COG0537	115	9e-28
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	BX548020	SYNW1134	COG0537	39	2e-04
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	BX548020	SYNW1233	COG0537	40	3e-04
Exopolyphosphatase	F	BX548020	SYNW1846	COG0248	367	1.0e-102
Formyltetrahydrofolate synthetase	F	BX548020	SYNW1831	COG2759	37	0.001
Guanylate kinase	F	BX548020	SYNW0026	COG0194	39	3e-04
Guanylate kinase	F	BX548020	SYNW0843	COG0194	34	0.008
Guanylate kinase	F	BX548020	SYNW1837	COG0194	239	8e-65
Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA	F	BX548020	SYNW1937	COG4445	170	7e-44
Nucleoside 2-deoxyribosyltransferase	F	BX548020	SYNW1812	COG3613	62	3e-11
Orotate phosphoribosyltransferase homologs	F	BX548020	SYNW0004	COG0856	39	8e-04
Orotate phosphoribosyltransferase homologs	F	BX548020	SYNW0238	COG0856	36	0.002
Orotate phosphoribosyltransferase homologs	F	BX548020	SYNW0520	COG0856	41	1e-04
Predicted alternative thymidylate synthase	F	BX548020	SYNW0279	COG1351	145	3e-36
Predicted nucleotide kinase	F	BX548020	SYNW2064	COG1618	41	3e-04

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	BX548020	SYNW0013	COG0015	111	8e-26
Adenylosuccinate lyase	F	BX548020	SYNW0405	COG0015	476	1.0e-135
Adenylosuccinate lyase	F	BX548020	SYNW0637	COG0015	105	6e-24
Adenylosuccinate synthase	F	BX548020	SYNW1773	COG0104	616	1.0e-177
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	BX548020	SYNW0249	COG0138	654	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	BX548020	SYNW0830	COG0138	45	3e-05
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	BX548020	SYNW1195	COG0299	64	2e-11
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	BX548020	SYNW1261	COG0299	235	2e-63
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	BX548020	SYNW2504	COG0299	133	1e-32
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW0336	COG0027	45	9e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW0552	COG0027	55	2e-08
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW0830	COG0027	63	1e-10
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW1308	COG0027	92	8e-20
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW1641	COG0027	36	0.004
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	BX548020	SYNW2519	COG0027	521	1.0e-149
Glutamine phosphoribosylpyrophosphate amidotransferase	F	BX548020	SYNW0004	COG0034	604	1.0e-174
Glutamine phosphoribosylpyrophosphate amidotransferase	F	BX548020	SYNW0145	COG0034	128	1e-30
Glutamine phosphoribosylpyrophosphate amidotransferase	F	BX548020	SYNW2453	COG0034	76	9e-15
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW0047	COG0518	210	2e-55
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW0435	COG0518	62	3e-11
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW0723	COG0518	65	3e-12
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW0793	COG0518	37	0.001
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW1026	COG0518	54	2e-08
GMP synthase - Glutamine amidotransferase domain	F	BX548020	SYNW2315	COG0518	87	9e-19
GMP synthase PP-ATPase domain/subunit	F	BX548020	SYNW0047	COG0519	534	1.0e-153
GMP synthase PP-ATPase domain/subunit	F	BX548020	SYNW0502	COG0519	36	0.006
GMP synthase PP-ATPase domain/subunit	F	BX548020	SYNW1622	COG0519	39	9e-04
GMP synthase PP-ATPase domain/subunit	F	BX548020	SYNW2051	COG0519	38	8e-04
IMP dehydrogenase/GMP reductase	F	BX548020	SYNW0725	COG0516	67	2e-12
Phosphoribosylamine-glycine ligase	F	BX548020	SYNW0336	COG0151	44	2e-05
Phosphoribosylamine-glycine ligase	F	BX548020	SYNW0552	COG0151	499	1.0e-142
Phosphoribosylamine-glycine ligase	F	BX548020	SYNW0830	COG0151	52	3e-07
Phosphoribosylamine-glycine ligase	F	BX548020	SYNW1384	COG0151	38	0.002
Phosphoribosylamine-glycine ligase	F	BX548020	SYNW2519	COG0151	64	1e-11
Phosphoribosylaminoimidazole (AIR) synthetase	F	BX548020	SYNW0003	COG0150	49	9e-07
Phosphoribosylaminoimidazole (AIR) synthetase	F	BX548020	SYNW0031	COG0150	40	2e-04
Phosphoribosylaminoimidazole (AIR) synthetase	F	BX548020	SYNW1422	COG0150	36	0.005
Phosphoribosylaminoimidazole (AIR) synthetase	F	BX548020	SYNW2029	COG0150	439	1.0e-125
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW0336	COG0026	66	4e-12
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW0552	COG0026	48	2e-06
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW0830	COG0026	44	7e-05
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW1308	COG0026	334	8e-93
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW1641	COG0026	44	2e-05
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	BX548020	SYNW2519	COG0026	210	1e-55
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	BX548020	SYNW0554	COG0152	282	1e-77
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	BX548020	SYNW1608	COG0041	52	4e-08
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	BX548020	SYNW2285	COG0041	200	5e-53
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	BX548020	SYNW0723	COG0047	36	0.002
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	BX548020	SYNW0793	COG0047	293	7e-81
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	BX548020	SYNW0794	COG1828	85	9e-19
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	BX548020	SYNW0003	COG0046	827	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	BX548020	SYNW1422	COG0046	65	6e-12
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	BX548020	SYNW2029	COG0046	44	1e-05
Phosphoribosylpyrophosphate synthetase	F	BX548020	SYNW0004	COG0462	37	0.003
Phosphoribosylpyrophosphate synthetase	F	BX548020	SYNW0520	COG0462	41	1e-04
Phosphoribosylpyrophosphate synthetase	F	BX548020	SYNW0966	COG0462	421	1.0e-119

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW0004	COG0503	47	4e-06
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW0520	COG0503	43	2e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW0814	COG0503	153	6e-39
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW0966	COG0503	46	4e-06
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW1813	COG0503	36	0.001
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	BX548020	SYNW1991	COG0503	41	5e-05
Formyltetrahydrofolate hydrolase	F	BX548020	SYNW1261	COG0788	120	9e-29
Formyltetrahydrofolate hydrolase	F	BX548020	SYNW2504	COG0788	373	1.0e-105
Hypoxanthine-guanine phosphoribosyltransferase	F	BX548020	SYNW0520	COG0634	54	1e-08
Hypoxanthine-guanine phosphoribosyltransferase	F	BX548020	SYNW0966	COG0634	39	5e-04
Purine nucleoside phosphorylase	F	BX548020	SYNW1265	COG0005	245	3e-66

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	BX548020	SYNW1344	COG0563	35	0.004
Adenylate kinase and related kinase	F	BX548020	SYNW2027	COG0563	49	6e-07
Adenylate kinase and related kinase	F	BX548020	SYNW2086	COG0563	166	8e-43
Adenylate kinase and related kinase	F	BX548020	SYNW2158	COG0563	37	0.005
Aspartate carbamoyltransferase catalytic chain	F	BX548020	SYNW0296	COG0540	318	4e-88
Aspartate carbamoyltransferase catalytic chain	F	BX548020	SYNW1586	COG0540	180	8e-47
Aspartate carbamoyltransferase catalytic chain	F	BX548020	SYNW2454	COG0540	210	1e-55
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW0336	COG0458	74	2e-14
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW0552	COG0458	55	1e-08
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW0830	COG0458	566	1.0e-162
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW1384	COG0458	44	3e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW1641	COG0458	56	3e-09
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	BX548020	SYNW2519	COG0458	50	3e-07
Carbamoylphosphate synthase small subunit	F	BX548020	SYNW0047	COG0505	71	1e-13
Carbamoylphosphate synthase small subunit	F	BX548020	SYNW0723	COG0505	39	2e-04
Carbamoylphosphate synthase small subunit	F	BX548020	SYNW1026	COG0505	493	1.0e-140
Carbamoylphosphate synthase small subunit	F	BX548020	SYNW2315	COG0505	84	6e-18
CTP synthase (UTP-ammonia lyase)	F	BX548020	SYNW2428	COG0504	860	0.0
Cytidylate kinase	F	BX548020	SYNW0094	COG1102	43	4e-05
Cytidylate kinase	F	BX548020	SYNW0094	COG0283	37	0.002
Cytidylate kinase	F	BX548020	SYNW0211	COG0283	36	0.002
Cytidylate kinase	F	BX548020	SYNW2027	COG1102	56	5e-09
Cytidylate kinase	F	BX548020	SYNW2027	COG0283	243	2e-65
Dihydroorotase and related cyclic amidohydrolase	F	BX548020	SYNW1523	COG0044	72	7e-14
Dihydroorotase and related cyclic amidohydrolase	F	BX548020	SYNW1764	COG0044	154	1e-38
Dihydroorotase and related cyclic amidohydrolase	F	BX548020	SYNW2449	COG0044	61	2e-10
Dihydroorotase	F	BX548020	SYNW1523	COG0418	497	1.0e-142
Dihydroorotase	F	BX548020	SYNW1764	COG0418	36	0.005
Dihydroorotate dehydrogenase	F	BX548020	SYNW0015	COG0167	39	4e-04
Dihydroorotate dehydrogenase	F	BX548020	SYNW0655	COG0167	51	2e-07
Dihydroorotate dehydrogenase	F	BX548020	SYNW0725	COG0167	38	0.002
Dihydroorotate dehydrogenase	F	BX548020	SYNW1855	COG0167	41	9e-05
Dihydroorotate dehydrogenase	F	BX548020	SYNW2337	COG0167	298	4e-82
Orotate phosphoribosyltransferase	F	BX548020	SYNW0004	COG0461	39	9e-04
Orotate phosphoribosyltransferase	F	BX548020	SYNW0238	COG0461	128	2e-31
Orotate phosphoribosyltransferase	F	BX548020	SYNW0520	COG0461	48	1e-06
Orotate phosphoribosyltransferase	F	BX548020	SYNW0814	COG0461	46	2e-06
Orotate phosphoribosyltransferase	F	BX548020	SYNW0966	COG0461	46	3e-06
Orotate phosphoribosyltransferase	F	BX548020	SYNW1991	COG0461	35	0.003
Orotidine-5'-phosphate decarboxylase	F	BX548020	SYNW0571	COG0284	183	8e-48
Orotidine-5'-phosphate decarboxylase	F	BX548020	SYNW1115	COG0284	39	3e-04
Uridylate kinase	F	BX548020	SYNW0070	COG0528	64	3e-11
Uridylate kinase	F	BX548020	SYNW0782	COG0528	51	2e-07
Uridylate kinase	F	BX548020	SYNW1752	COG0528	319	2e-88

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	BX548020	SYNW0520	COG2065	179	2e-46
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	BX548020	SYNW0966	COG2065	38	8e-04

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytidine deaminase	F	BX548020	SYNW1811	COG0295	124	2e-30
Cytosine deaminase and related metal-dependent hydrolase	F	BX548020	SYNW1638	COG0402	112	5e-26
Cytosine deaminase and related metal-dependent hydrolase	F	BX548020	SYNW2449	COG0402	46	7e-06
Nucleoside phosphorylase	F	BX548020	SYNW0169	COG0775	141	4e-35
Purine-nucleoside phosphorylase	F	BX548020	SYNW0169	COG0813	40	1e-04
Thymidine phosphorylase	F	BX548020	SYNW1025	COG0213	51	1e-07
Uracil phosphoribosyltransferase	F	BX548020	SYNW0520	COG0035	38	8e-04
Uracil phosphoribosyltransferase	F	BX548020	SYNW0966	COG0035	35	0.009
Uracil phosphoribosyltransferase	F	BX548020	SYNW1125	COG0035	120	9e-29
Uridine kinase	F	BX548020	SYNW0217	COG0572	38	0.003
Uridine kinase	F	BX548020	SYNW0785	COG0572	48	1e-06
Uridine kinase	F	BX548020	SYNW1209	COG0572	55	6e-09
Uridine kinase	F	BX548020	SYNW1344	COG0572	99	2e-22

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	BX548020	SYNW0054	COG2022	351	2e-98
Uncharacterized protein of thiazole biosynthesis	F	BX548020	SYNW0725	COG2022	36	0.003

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	BX548020	SYNW0278	COG0717	161	3e-41
Nucleoside diphosphate kinase	F	BX548020	SYNW2358	COG0105	210	4e-56
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	BX548020	SYNW1984	COG1328	33	0.009
Ribonucleotide reductase alpha subunit	F	BX548020	SYNW1147	COG0209	37	0.004
Thymidylate kinase	F	BX548020	SYNW2086	COG0125	34	0.008
Thymidylate kinase	F	BX548020	SYNW2238	COG0125	191	4e-50

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Xanthine/uracil permease	F	BX548020	SYNW0839	COG2233	39	0.001
Xanthine/uracil permease	F	BX548020	SYNW1524	COG2233	50	3e-07
Xanthine/uracil permease	F	BX548020	SYNW1936	COG2233	38	0.002
Xanthine/uracil permease	F	BX548020	SYNW2321	COG2233	36	0.005
Xanthosine triphosphate pyrophosphatase	F	BX548020	SYNW0234	COG0127	207	4e-55
Xanthosine triphosphate pyrophosphatase	F	BX548020	SYNW1720	COG0127	157	5e-40

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