Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine deaminase	F	Contig6	Nwi2008	COG1001	48	1e-06
Adenine deaminase	F	Contig6	Nwi2703	COG1001	53	4e-08
Adenosine deaminase	F	Contig6	Nwi0203	COG2169	69	5e-13
ADP-ribose pyrophosphatase	F	Contig6	Nwi0387	COG1051	54	3e-09
ADP-ribose pyrophosphatase	F	Contig6	Nwi0451	COG1051	37	6e-04
ADP-ribose pyrophosphatase	F	Contig6	Nwi2624	COG1051	37	0.001
ADP-ribose pyrophosphatase	F	Contig6	Nwi2633	COG1051	45	2e-06
ADP-ribose pyrophosphatase	F	Contig6	Nwi2700	COG1051	79	1e-16
Cytosine/adenosine deaminase	F	Contig6	Nwi1725	COG0590	74	2e-14
Cytosine/adenosine deaminase	F	Contig6	Nwi2551	COG0590	174	2e-45
Deoxycytidylate deaminase	F	Contig6	Nwi1725	COG2131	68	1e-12
Deoxycytidylate deaminase	F	Contig6	Nwi2551	COG2131	52	3e-08
Deoxynucleoside kinase	F	Contig6	Nwi0208	COG1428	37	0.001
dGTP triphosphohydrolase	F	Contig6	Nwi1808	COG0232	388	1.0e-109
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig6	Nwi0370	COG0537	67	4e-13
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig6	Nwi2416	COG0537	125	1e-30
Exopolyphosphatase	F	Contig6	Nwi1593	COG0248	320	1e-88
Exopolyphosphatase	F	Contig6	Nwi2151	COG0248	281	5e-77
Guanylate kinase	F	Contig6	Nwi1526	COG0194	37	0.001
Guanylate kinase	F	Contig6	Nwi1683	COG0194	245	2e-66
Orotate phosphoribosyltransferase homologs	F	Contig6	Nwi0153	COG0856	36	0.002
Orotate phosphoribosyltransferase homologs	F	Contig6	Nwi0385	COG0856	36	0.003
Orotate phosphoribosyltransferase homologs	F	Contig6	Nwi2017	COG0856	53	7e-08
Orotate phosphoribosyltransferase homologs	F	Contig6	Nwi2613	COG0856	39	3e-04
Predicted nucleotide kinase	F	Contig6	Nwi0933	COG1618	38	6e-04
Predicted nucleotide kinase	F	Contig6	Nwi2240	COG1618	36	0.005
Predicted nucleotide kinase	F	Contig6	Nwi2764	COG4088	46	1e-05
Predicted nucleotide kinase	F	Contig6	Nwi2927	COG1618	35	0.008
Predicted nucleotide kinase	F	Contig6	Nwi3002	COG1618	46	3e-06

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig6	Nwi0715	COG0015	112	6e-26
Adenylosuccinate lyase	F	Contig6	Nwi2167	COG0015	524	1.0e-150
Adenylosuccinate lyase	F	Contig6	Nwi2353	COG0015	100	2e-22
Adenylosuccinate synthase	F	Contig6	Nwi2965	COG0104	633	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig6	Nwi0158	COG0138	747	0.0
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig6	Nwi1598	COG0299	235	1e-63
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig6	Nwi2382	COG0299	126	2e-30
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig6	Nwi3065	COG0299	73	2e-14
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi1001	COG0027	134	1e-32
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi1604	COG0027	45	2e-05
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi1736	COG0027	50	6e-07
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi1753	COG0027	58	2e-09
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi2401	COG0027	37	0.002
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi2449	COG0027	42	2e-04
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig6	Nwi2552	COG0027	41	2e-04
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig6	Nwi0385	COG0034	37	0.002
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig6	Nwi1517	COG0034	132	8e-32
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig6	Nwi2017	COG0034	637	0.0
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig6	Nwi2613	COG0034	36	0.001
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi0124	COG0518	60	1e-10
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi0951	COG0518	78	2e-15
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi2143	COG0518	205	9e-54
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi2391	COG0518	54	6e-09
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi2446	COG0518	81	1e-16
GMP synthase - Glutamine amidotransferase domain	F	Contig6	Nwi2614	COG0518	71	4e-13
GMP synthase PP-ATPase domain/subunit	F	Contig6	Nwi0603	COG0519	38	0.001
GMP synthase PP-ATPase domain/subunit	F	Contig6	Nwi2143	COG0519	556	1.0e-159
IMP dehydrogenase/GMP reductase	F	Contig6	Nwi2146	COG0516	134	1e-32
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi1055	COG0151	40	3e-04
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi1604	COG0151	56	1e-08
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi1736	COG0151	49	8e-07
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi1753	COG0151	48	1e-06
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi2449	COG0151	37	0.009
Phosphoribosylamine-glycine ligase	F	Contig6	Nwi2552	COG0151	574	1.0e-165
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig6	Nwi1308	COG0150	47	4e-06
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig6	Nwi1597	COG0150	440	1.0e-125
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig6	Nwi1721	COG0150	58	1e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi0420	COG0026	37	0.003
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi1001	COG0026	418	1.0e-118
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi1055	COG0026	45	9e-06
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi1604	COG0026	49	1e-06
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi1736	COG0026	58	2e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi1753	COG0026	64	3e-11
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi2449	COG0026	49	1e-06
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig6	Nwi2552	COG0026	38	0.002
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig6	Nwi1304	COG0152	328	3e-91
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig6	Nwi1002	COG0041	211	2e-56
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig6	Nwi1306	COG0047	317	6e-88
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig6	Nwi2143	COG0047	40	5e-04
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig6	Nwi2391	COG0047	42	4e-05
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	Contig6	Nwi1305	COG1828	95	9e-22
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig6	Nwi1308	COG0046	888	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig6	Nwi1597	COG0046	38	0.001
Phosphoribosylpyrophosphate synthetase	F	Contig6	Nwi0385	COG0462	37	0.001
Phosphoribosylpyrophosphate synthetase	F	Contig6	Nwi2188	COG0462	37	7e-04
Phosphoribosylpyrophosphate synthetase	F	Contig6	Nwi2501	COG0462	408	1.0e-115
Phosphoribosylpyrophosphate synthetase	F	Contig6	Nwi2613	COG0462	42	2e-05

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi0153	COG0503	47	9e-07
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi0385	COG0503	40	2e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi2017	COG0503	46	8e-06
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi2188	COG0503	85	3e-18
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi2501	COG0503	39	4e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig6	Nwi2613	COG0503	176	1e-45
Formyltetrahydrofolate hydrolase	F	Contig6	Nwi1598	COG0788	127	7e-31
Formyltetrahydrofolate hydrolase	F	Contig6	Nwi2382	COG0788	403	1.0e-114
Formyltetrahydrofolate hydrolase	F	Contig6	Nwi3065	COG0788	53	3e-08
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig6	Nwi0385	COG0634	40	2e-04
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig6	Nwi2017	COG0634	40	3e-04
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig6	Nwi2188	COG0634	40	6e-05
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig6	Nwi2501	COG0634	40	2e-04

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig6	Nwi0208	COG0563	49	2e-07
Adenylate kinase and related kinase	F	Contig6	Nwi1233	COG0563	36	0.007
Adenylate kinase and related kinase	F	Contig6	Nwi1385	COG0563	181	3e-47
Adenylate kinase and related kinase	F	Contig6	Nwi2724	COG0563	36	0.006
Aspartate carbamoyltransferase catalytic chain	F	Contig6	Nwi0514	COG0540	175	4e-45
Aspartate carbamoyltransferase catalytic chain	F	Contig6	Nwi2007	COG0540	374	1.0e-105
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi1001	COG0458	41	1e-04
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi1604	COG0458	67	5e-12
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi1736	COG0458	83	8e-17
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi1753	COG0458	71	2e-13
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi2449	COG0458	540	1.0e-154
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig6	Nwi2552	COG0458	39	6e-04
Carbamoylphosphate synthase small subunit	F	Contig6	Nwi0951	COG0505	62	1e-10
Carbamoylphosphate synthase small subunit	F	Contig6	Nwi1833	COG0505	37	0.004
Carbamoylphosphate synthase small subunit	F	Contig6	Nwi2143	COG0505	62	1e-10
Carbamoylphosphate synthase small subunit	F	Contig6	Nwi2446	COG0505	547	1.0e-157
Carbamoylphosphate synthase small subunit	F	Contig6	Nwi2614	COG0505	91	3e-19
CTP synthase (UTP-ammonia lyase)	F	Contig6	Nwi0124	COG0504	35	0.004
CTP synthase (UTP-ammonia lyase)	F	Contig6	Nwi1833	COG0504	851	0.0
CTP synthase (UTP-ammonia lyase)	F	Contig6	Nwi2143	COG0504	44	4e-05
CTP synthase (UTP-ammonia lyase)	F	Contig6	Nwi2446	COG0504	36	0.004
CTP synthase (UTP-ammonia lyase)	F	Contig6	Nwi2614	COG0504	40	7e-04
Cytidylate kinase	F	Contig6	Nwi0208	COG1102	58	5e-10
Cytidylate kinase	F	Contig6	Nwi0208	COG0283	206	1e-54
Cytidylate kinase	F	Contig6	Nwi0395	COG1102	39	3e-04
Cytidylate kinase	F	Contig6	Nwi1385	COG1102	35	0.003
Cytidylate kinase	F	Contig6	Nwi1385	COG0283	36	0.002
Dihydroorotase and related cyclic amidohydrolase	F	Contig6	Nwi2008	COG0044	398	1.0e-112
Dihydroorotase and related cyclic amidohydrolase	F	Contig6	Nwi2703	COG0044	417	1.0e-118
Dihydroorotase	F	Contig6	Nwi2008	COG0418	39	5e-04
Dihydroorotase	F	Contig6	Nwi2703	COG0418	38	0.001
Dihydroorotate dehydrogenase	F	Contig6	Nwi0464	COG0167	287	1e-78
Dihydroorotate dehydrogenase	F	Contig6	Nwi0702	COG0167	51	1e-07
Dihydroorotate dehydrogenase	F	Contig6	Nwi1443	COG0167	56	3e-09
Dihydroorotate dehydrogenase	F	Contig6	Nwi2146	COG0167	38	0.001
Dihydroorotate dehydrogenase	F	Contig6	Nwi2390	COG0167	36	0.003
Dihydroorotate dehydrogenase	F	Contig6	Nwi2817	COG0167	46	3e-06
Orotate phosphoribosyltransferase	F	Contig6	Nwi0153	COG0461	128	2e-31
Orotate phosphoribosyltransferase	F	Contig6	Nwi0385	COG0461	38	0.001
Orotate phosphoribosyltransferase	F	Contig6	Nwi2501	COG0461	39	5e-04
Orotate phosphoribosyltransferase	F	Contig6	Nwi2613	COG0461	56	2e-09
Orotidine-5'-phosphate decarboxylase	F	Contig6	Nwi1862	COG0284	200	6e-53
Uridylate kinase	F	Contig6	Nwi0379	COG0528	72	6e-14
Uridylate kinase	F	Contig6	Nwi0443	COG0528	46	4e-06
Uridylate kinase	F	Contig6	Nwi0949	COG0528	74	9e-15
Uridylate kinase	F	Contig6	Nwi0950	COG0528	68	1e-12
Uridylate kinase	F	Contig6	Nwi1857	COG0528	292	1e-80

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig6	Nwi0385	COG2065	36	0.004

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytosine deaminase and related metal-dependent hydrolase	F	Contig6	Nwi2008	COG0402	38	0.001
Cytosine deaminase and related metal-dependent hydrolase	F	Contig6	Nwi2703	COG0402	60	4e-10
Nucleoside phosphorylase	F	Contig6	Nwi2268	COG0775	55	6e-09
Nucleoside phosphorylase	F	Contig6	Nwi3067	COG0775	78	4e-16
Thymidine phosphorylase	F	Contig6	Nwi1837	COG0213	62	6e-11
Uridine kinase	F	Contig6	Nwi0120	COG0572	70	3e-13
Uridine kinase	F	Contig6	Nwi2693	COG0572	54	9e-09

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig6	Nwi2390	COG2022	38	8e-04
Uncharacterized protein of thiazole biosynthesis	F	Contig6	Nwi2466	COG2022	353	9e-99

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig6	Nwi0044	COG0717	59	1e-10
Deoxycytidine deaminase	F	Contig6	Nwi0140	COG0717	122	4e-29
dUTPase	F	Contig6	Nwi0044	COG0756	176	6e-46
Nucleoside diphosphate kinase	F	Contig6	Nwi1601	COG0105	191	1e-50
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig6	Nwi1726	COG1328	37	7e-04
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig6	Nwi2888	COG1328	63	9e-11
Ribonucleotide reductase alpha subunit	F	Contig6	Nwi1571	COG0209	302	1e-82
Ribonucleotide reductase alpha subunit	F	Contig6	Nwi2888	COG0209	572	1.0e-164
Ribonucleotide reductase beta subunit	F	Contig6	Nwi2887	COG0208	331	5e-92
Thymidylate kinase	F	Contig6	Nwi0104	COG0125	34	0.006
Thymidylate kinase	F	Contig6	Nwi1464	COG0125	218	2e-58
Thymidylate kinase	F	Contig6	Nwi1683	COG0125	35	0.003
Thymidylate synthase	F	Contig6	Nwi2351	COG0207	430	1.0e-122

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig6	Nwi2204	COG4630	100	2e-22
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig6	Nwi2205	COG4630	119	1e-28
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig6	Nwi1079	COG4631	233	4e-62
Xanthine/uracil permease	F	Contig6	Nwi2065	COG2233	43	5e-05
Xanthosine triphosphate pyrophosphatase	F	Contig6	Nwi0192	COG0127	204	3e-54

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