Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine deaminase	F	Contig12	NmulA0963	COG1001	48	1e-06
Adenine deaminase	F	Contig12	NmulA1241	COG1001	43	4e-05
Adenine deaminase	F	Contig12	NmulA2187	COG1001	42	1e-04
Adenine deaminase	F	Contig12	NmulA2482	COG1001	46	5e-06
Adenosine deaminase	F	Contig12	NmulA0916	COG2169	48	8e-07
ADP-ribose pyrophosphatase	F	Contig12	NmulA0449	COG1051	47	6e-07
ADP-ribose pyrophosphatase	F	Contig12	NmulA0604	COG1051	47	9e-07
ADP-ribose pyrophosphatase	F	Contig12	NmulA1007	COG1051	54	1e-08
ADP-ribose pyrophosphatase	F	Contig12	NmulA2233	COG1051	45	4e-06
ADP-ribose pyrophosphatase	F	Contig12	NmulA2244	COG1051	55	2e-09
ADP-ribose pyrophosphatase	F	Contig12	NmulA2533	COG1051	100	8e-23
ADP-ribose pyrophosphatase	F	Contig12	NmulA2646	COG1051	42	1e-05
Cytosine/adenosine deaminase	F	Contig12	NmulA0006	COG0590	70	3e-13
Cytosine/adenosine deaminase	F	Contig12	NmulA0119	COG0590	45	1e-05
Cytosine/adenosine deaminase	F	Contig12	NmulA0144	COG0590	116	9e-28
Cytosine/adenosine deaminase	F	Contig12	NmulA1225	COG0590	177	5e-46
Cytosine/uracil/thiamine/allantoin permease	F	Contig12	NmulA1373	COG1953	39	0.003
Deoxycytidylate deaminase	F	Contig12	NmulA0006	COG2131	74	1e-14
Deoxycytidylate deaminase	F	Contig12	NmulA0119	COG2131	121	8e-29
Deoxycytidylate deaminase	F	Contig12	NmulA0144	COG2131	45	2e-06
Deoxycytidylate deaminase	F	Contig12	NmulA1225	COG2131	53	8e-09
Deoxynucleoside kinase	F	Contig12	NmulA0880	COG1428	143	7e-36
Deoxynucleoside kinase	F	Contig12	NmulA1244	COG1428	35	0.004
dGTP triphosphohydrolase	F	Contig12	NmulA0704	COG0232	359	1.0e-100
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig12	NmulA0423	COG0537	65	2e-12
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig12	NmulA0811	COG0537	116	5e-28
Exopolyphosphatase	F	Contig12	NmulA0434	COG0248	409	1.0e-115
Guanylate kinase	F	Contig12	NmulA0052	COG0194	245	2e-66
Guanylate kinase	F	Contig12	NmulA2749	COG0194	35	0.007
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA0225	COG0856	52	3e-08
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA0589	COG0856	44	1e-05
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA0935	COG0856	40	1e-04
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA1128	COG0856	38	5e-04
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA1906	COG0856	45	1e-05
Orotate phosphoribosyltransferase homologs	F	Contig12	NmulA2480	COG0856	35	0.003
Predicted nucleotide kinase	F	Contig12	NmulA0912	COG4088	40	6e-04
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig12	NmulA0880	COG1936	41	8e-05

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig12	NmulA2241	COG0015	364	1.0e-102
Adenylosuccinate lyase	F	Contig12	NmulA2328	COG0015	123	4e-29
Adenylosuccinate lyase	F	Contig12	NmulA2471	COG0015	100	2e-22
Adenylosuccinate synthase	F	Contig12	NmulA0441	COG0104	631	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig12	NmulA0133	COG0138	775	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig12	NmulA0479	COG0138	46	2e-05
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig12	NmulA0393	COG0299	85	5e-18
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig12	NmulA2618	COG0299	277	5e-76
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA0134	COG0027	46	8e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA0479	COG0027	66	1e-11
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA0611	COG0027	121	1e-28
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA2250	COG0027	43	1e-04
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA2251	COG0027	41	3e-04
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA2491	COG0027	50	2e-07
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig12	NmulA2752	COG0027	50	5e-07
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig12	NmulA0225	COG0034	35	0.004
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig12	NmulA0313	COG0034	139	4e-34
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig12	NmulA1128	COG0034	39	3e-04
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig12	NmulA1906	COG0034	610	1.0e-176
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig12	NmulA2519	COG0034	86	6e-18
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA0478	COG0518	66	4e-12
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA0816	COG0518	49	2e-07
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA1045	COG0518	155	2e-39
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA1199	COG0518	207	2e-54
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA1549	COG0518	48	8e-07
GMP synthase - Glutamine amidotransferase domain	F	Contig12	NmulA2564	COG0518	84	6e-18
GMP synthase PP-ATPase domain/subunit	F	Contig12	NmulA1199	COG0519	545	1.0e-156
GMP synthase PP-ATPase domain/subunit	F	Contig12	NmulA2243	COG0519	38	0.001
IMP dehydrogenase/GMP reductase	F	Contig12	NmulA1200	COG0516	131	2e-31
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA0134	COG0151	541	1.0e-155
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA0479	COG0151	57	8e-09
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA1079	COG0151	37	0.003
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA1996	COG0151	41	1e-04
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA2250	COG0151	37	0.007
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA2251	COG0151	49	9e-07
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA2491	COG0151	37	0.001
Phosphoribosylamine-glycine ligase	F	Contig12	NmulA2752	COG0151	59	6e-10
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig12	NmulA1669	COG0150	70	2e-13
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig12	NmulA2617	COG0150	486	1.0e-138
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA0134	COG0026	50	3e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA0479	COG0026	57	8e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA0611	COG0026	443	1.0e-125
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA2191	COG0026	38	0.002
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA2250	COG0026	48	4e-06
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA2251	COG0026	53	6e-08
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA2491	COG0026	49	5e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig12	NmulA2752	COG0026	73	3e-14
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig12	NmulA0612	COG0152	207	6e-55
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig12	NmulA0610	COG0041	221	3e-59
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig12	NmulA0816	COG0047	41	5e-05
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig12	NmulA1549	COG0047	36	0.003
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig12	NmulA2383	COG0047	253	5e-68
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig12	NmulA1669	COG0046	50	2e-07
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig12	NmulA2383	COG0046	697	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig12	NmulA2617	COG0046	44	2e-05
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA0589	COG0462	417	1.0e-118
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA0649	COG0462	37	7e-04
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA0900	COG0462	42	3e-05
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA0935	COG0462	36	0.001
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA1128	COG0462	41	7e-05
Phosphoribosylpyrophosphate synthetase	F	Contig12	NmulA1906	COG0462	39	7e-04

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig12	NmulA0225	COG0503	49	3e-07
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig12	NmulA0935	COG0503	177	3e-46
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig12	NmulA1128	COG0503	40	1e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig12	NmulA1906	COG0503	41	2e-04
Formyltetrahydrofolate hydrolase	F	Contig12	NmulA0393	COG0788	46	3e-06
Formyltetrahydrofolate hydrolase	F	Contig12	NmulA2618	COG0788	139	2e-34
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA0225	COG0634	35	0.006
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA0589	COG0634	37	0.002
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA0649	COG0634	166	9e-43
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA0900	COG0634	40	2e-04
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA1128	COG0634	35	0.007
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig12	NmulA2480	COG0634	63	1e-11
Purine nucleoside phosphorylase	F	Contig12	NmulA0650	COG0005	214	6e-57

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig12	NmulA0741	COG0563	164	4e-42
Adenylate kinase and related kinase	F	Contig12	NmulA1280	COG0563	37	0.005
Adenylate kinase and related kinase	F	Contig12	NmulA1972	COG0563	34	0.006
Adenylate kinase and related kinase	F	Contig12	NmulA2070	COG0563	45	5e-06
Aspartate carbamoyltransferase catalytic chain	F	Contig12	NmulA1042	COG0540	156	2e-39
Aspartate carbamoyltransferase catalytic chain	F	Contig12	NmulA2481	COG0540	357	1.0e-100
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA0134	COG0458	44	2e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA0479	COG0458	579	1.0e-166
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA0611	COG0458	37	0.002
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA0943	COG0458	68	3e-12
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA1722	COG0458	48	2e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA2250	COG0458	49	1e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA2251	COG0458	61	3e-10
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA2491	COG0458	65	7e-12
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig12	NmulA2752	COG0458	82	9e-17
Carbamoylphosphate synthase small subunit	F	Contig12	NmulA0478	COG0505	563	1.0e-162
Carbamoylphosphate synthase small subunit	F	Contig12	NmulA1045	COG0505	38	6e-04
Carbamoylphosphate synthase small subunit	F	Contig12	NmulA1199	COG0505	59	6e-10
Carbamoylphosphate synthase small subunit	F	Contig12	NmulA1549	COG0505	48	8e-07
Carbamoylphosphate synthase small subunit	F	Contig12	NmulA2564	COG0505	81	4e-17
CTP synthase (UTP-ammonia lyase)	F	Contig12	NmulA1227	COG0504	859	0.0
CTP synthase (UTP-ammonia lyase)	F	Contig12	NmulA1549	COG0504	46	3e-06
Cytidylate kinase	F	Contig12	NmulA2070	COG1102	49	2e-07
Cytidylate kinase	F	Contig12	NmulA2070	COG0283	245	2e-66
Cytidylate kinase	F	Contig12	NmulA2738	COG1102	39	3e-04
Dihydroorotase and related cyclic amidohydrolase	F	Contig12	NmulA0354	COG0044	56	3e-09
Dihydroorotase and related cyclic amidohydrolase	F	Contig12	NmulA0963	COG0044	44	2e-05
Dihydroorotase and related cyclic amidohydrolase	F	Contig12	NmulA1241	COG0044	63	6e-11
Dihydroorotase and related cyclic amidohydrolase	F	Contig12	NmulA2187	COG0044	41	1e-04
Dihydroorotase and related cyclic amidohydrolase	F	Contig12	NmulA2482	COG0044	368	1.0e-103
Dihydroorotase	F	Contig12	NmulA0354	COG0418	515	1.0e-147
Dihydroorotate dehydrogenase	F	Contig12	NmulA0131	COG0167	56	5e-09
Dihydroorotate dehydrogenase	F	Contig12	NmulA0815	COG0167	35	0.007
Dihydroorotate dehydrogenase	F	Contig12	NmulA1200	COG0167	40	4e-04
Dihydroorotate dehydrogenase	F	Contig12	NmulA2628	COG0167	43	2e-05
Dihydroorotate dehydrogenase	F	Contig12	NmulA2706	COG0167	300	7e-83
Orotate phosphoribosyltransferase	F	Contig12	NmulA0225	COG0461	181	4e-47
Orotate phosphoribosyltransferase	F	Contig12	NmulA0589	COG0461	43	3e-05
Orotate phosphoribosyltransferase	F	Contig12	NmulA0935	COG0461	58	5e-10
Orotate phosphoribosyltransferase	F	Contig12	NmulA1128	COG0461	35	0.004
Orotate phosphoribosyltransferase	F	Contig12	NmulA2480	COG0461	34	0.004
Orotidine-5'-phosphate decarboxylase	F	Contig12	NmulA2066	COG0284	240	9e-65
Uridylate kinase	F	Contig12	NmulA0659	COG0528	312	1e-86
Uridylate kinase	F	Contig12	NmulA1843	COG0528	68	9e-13
Uridylate kinase	F	Contig12	NmulA1941	COG0528	64	2e-11

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig12	NmulA0649	COG2065	34	0.007
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig12	NmulA0900	COG2065	40	1e-04
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig12	NmulA2480	COG2065	156	6e-40

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytosine deaminase and related metal-dependent hydrolase	F	Contig12	NmulA0963	COG0402	42	9e-05
Cytosine deaminase and related metal-dependent hydrolase	F	Contig12	NmulA1241	COG0402	42	2e-04
Cytosine deaminase and related metal-dependent hydrolase	F	Contig12	NmulA2187	COG0402	295	6e-81
Cytosine deaminase and related metal-dependent hydrolase	F	Contig12	NmulA2482	COG0402	48	2e-06
Nucleoside phosphorylase	F	Contig12	NmulA0542	COG0775	78	1e-15
Nucleoside phosphorylase	F	Contig12	NmulA2555	COG0775	50	2e-07
Thymidine kinase	F	Contig12	NmulA2525	COG1435	35	0.007
Thymidine phosphorylase	F	Contig12	NmulA2563	COG0213	50	3e-07
Uracil phosphoribosyltransferase	F	Contig12	NmulA0900	COG0035	44	1e-05
Uracil phosphoribosyltransferase	F	Contig12	NmulA2480	COG0035	39	3e-04
Uridine kinase	F	Contig12	NmulA0562	COG0572	51	1e-07
Uridine kinase	F	Contig12	NmulA1244	COG0572	38	7e-04
Uridine kinase	F	Contig12	NmulA2070	COG0572	37	0.001
Uridine kinase	F	Contig12	NmulA2749	COG0572	38	0.001

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig12	NmulA0070	COG2022	361	1.0e-101

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig12	NmulA1965	COG0717	215	2e-57
Deoxycytidine deaminase	F	Contig12	NmulA2136	COG0717	48	3e-07
dUTPase	F	Contig12	NmulA2136	COG0756	183	5e-48
Nucleoside diphosphate kinase	F	Contig12	NmulA2380	COG0105	208	1e-55
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig12	NmulA2468	COG1328	62	2e-10
Ribonucleotide reductase alpha subunit	F	Contig12	NmulA2468	COG0209	590	1.0e-169
Ribonucleotide reductase beta subunit	F	Contig12	NmulA2469	COG0208	366	1.0e-102
Thymidylate kinase	F	Contig12	NmulA0880	COG0125	51	6e-08
Thymidylate kinase	F	Contig12	NmulA1387	COG0125	230	6e-62
Thymidylate kinase	F	Contig12	NmulA2738	COG0125	35	0.009
Thymidylate synthase	F	Contig12	NmulA1962	COG0207	410	1.0e-116

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Xanthosine triphosphate pyrophosphatase	F	Contig12	NmulA0067	COG0127	232	1e-62

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