Coenzyme Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
5 10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	H	Contig28	Nham0609	COG0190	355	3e-99
5 10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	H	Contig28	Nham1227	COG0190	36	0.006
5-formyltetrahydrofolate cyclo-ligase	H	Contig28	Nham3528	COG0212	149	1e-37
6-pyruvoyl-tetrahydropterin synthase	H	Contig28	Nham3244	COG0720	97	4e-22
7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	H	Contig28	Nham2635	COG0801	168	3e-43
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig26	Nham4523	COG1120	59	7e-10
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig27	Nham4198	COG1120	110	2e-25
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0003	COG1120	36	0.005
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0176	COG1120	164	6e-42
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0346	COG1120	142	2e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0355	COG1120	144	6e-36
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0356	COG1120	154	7e-39
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0382	COG1120	147	2e-36
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0409	COG1120	115	2e-27
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0417	COG1120	136	4e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0426	COG1120	134	6e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0433	COG1120	132	2e-32
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0549	COG1120	112	2e-26
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0638	COG1120	159	2e-40
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0667	COG1120	137	8e-34
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0718	COG1120	141	6e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0741	COG1120	40	5e-04
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0905	COG1120	129	2e-31
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0955	COG1120	254	4e-69
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham0964	COG1120	151	6e-38
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1051	COG1120	124	2e-29
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1207	COG1120	168	4e-43
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1292	COG1120	133	4e-32
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1316	COG1120	158	3e-40
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1492	COG1120	141	2e-34
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1534	COG1120	144	2e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1672	COG1120	126	2e-30
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1673	COG1120	124	4e-30
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham1922	COG1120	149	2e-37
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2068	COG1120	165	3e-42
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2081	COG1120	64	4e-11
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2195	COG1120	134	6e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2327	COG1120	94	6e-21
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2336	COG1120	99	9e-22
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2538	COG1120	153	5e-38
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2552	COG1120	119	6e-28
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2613	COG1120	116	2e-27
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2614	COG1120	150	1e-37
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2718	COG1120	163	2e-41
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2740	COG1120	159	2e-40
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2779	COG1120	74	7e-15
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2808	COG1120	136	1e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2809	COG1120	133	3e-32
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2911	COG1120	114	2e-26
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2948	COG1120	127	3e-30
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham2970	COG1120	101	1e-22
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3026	COG1120	124	2e-29
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3048	COG1120	143	7e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3230	COG1120	37	0.007
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3428	COG1120	181	4e-47
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3544	COG1120	159	4e-40
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3557	COG1120	169	2e-43
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3648	COG1120	148	5e-37
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3649	COG1120	128	4e-31
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3707	COG1120	42	4e-04
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3729	COG1120	239	1e-64
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3736	COG1120	135	1e-32
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig28	Nham3991	COG1120	107	3e-24
ABC-type cobalamin transport system ATPase component	H	Contig27	Nham4198	COG4138	43	5e-05
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0176	COG4138	86	3e-18
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0346	COG4138	58	4e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0355	COG4138	66	3e-12
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0356	COG4138	55	7e-09
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0382	COG4138	71	2e-13
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0409	COG4138	55	4e-09
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0417	COG4138	74	4e-14
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0426	COG4138	61	9e-11
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0433	COG4138	78	6e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0549	COG4138	53	1e-08
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0638	COG4138	65	7e-12
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0667	COG4138	65	5e-12
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0718	COG4138	82	4e-17
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0905	COG4138	54	1e-08
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0955	COG4138	103	2e-23
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham0964	COG4138	74	1e-14
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1051	COG4138	70	6e-13
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1207	COG4138	80	2e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1292	COG4138	85	2e-17
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1316	COG4138	87	2e-18
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1492	COG4138	62	1e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1534	COG4138	71	3e-13
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1672	COG4138	54	1e-08
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1673	COG4138	72	5e-14
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham1922	COG4138	74	8e-15
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2068	COG4138	60	1e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2081	COG4138	49	2e-06
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2195	COG4138	54	1e-08
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2327	COG4138	59	3e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2336	COG4138	58	2e-09
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2538	COG4138	80	5e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2552	COG4138	59	7e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2613	COG4138	37	0.002
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2614	COG4138	75	6e-15
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2718	COG4138	80	1e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2740	COG4138	80	1e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2779	COG4138	42	3e-05
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2808	COG4138	80	9e-17
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2809	COG4138	78	2e-15
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2911	COG4138	51	2e-07
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2948	COG4138	67	3e-12
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham2970	COG4138	52	1e-07
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3026	COG4138	75	1e-14
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3048	COG4138	66	1e-11
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3428	COG4138	85	3e-18
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3544	COG4138	80	4e-16
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3557	COG4138	77	2e-15
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3648	COG4138	61	1e-10
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3649	COG4138	54	1e-08
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3729	COG4138	108	6e-25
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3736	COG4138	70	5e-13
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3841	COG4138	41	5e-04
ABC-type cobalamin transport system ATPase component	H	Contig28	Nham3991	COG4138	45	1e-05
ABC-type cobalamin transport system permease component	H	Contig28	Nham0954	COG4139	147	1e-36
ABC-type cobalamin transport system permease component	H	Contig28	Nham3730	COG4139	137	1e-33
ABC-type thiamine transport system ATPase component	H	Contig25	Nham4566	COG3840	39	0.002
ABC-type thiamine transport system ATPase component	H	Contig26	Nham4523	COG3840	48	2e-06
ABC-type thiamine transport system ATPase component	H	Contig27	Nham4198	COG3840	78	1e-15
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0176	COG3840	111	6e-26
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0346	COG3840	134	5e-33
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0355	COG3840	83	1e-17
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0356	COG3840	106	2e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0382	COG3840	117	2e-27
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0409	COG3840	86	2e-18
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0417	COG3840	125	8e-30
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0426	COG3840	140	1e-34
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0433	COG3840	144	4e-36
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0549	COG3840	103	1e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0638	COG3840	105	4e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0667	COG3840	104	7e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0718	COG3840	106	2e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0905	COG3840	121	5e-29
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0955	COG3840	102	4e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham0964	COG3840	107	8e-25
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1051	COG3840	104	2e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1207	COG3840	179	2e-46
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1292	COG3840	104	3e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1316	COG3840	137	6e-34
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1492	COG3840	116	7e-27
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1534	COG3840	133	3e-32
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1672	COG3840	104	7e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1673	COG3840	85	5e-18
ABC-type thiamine transport system ATPase component	H	Contig28	Nham1922	COG3840	122	2e-29
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2068	COG3840	157	5e-40
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2081	COG3840	43	7e-05
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2195	COG3840	110	8e-26
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2327	COG3840	63	2e-11
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2336	COG3840	58	3e-09
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2538	COG3840	101	2e-22
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2552	COG3840	84	3e-17
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2613	COG3840	81	8e-17
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2614	COG3840	104	6e-24
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2718	COG3840	134	6e-33
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2740	COG3840	111	8e-26
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2779	COG3840	64	8e-12
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2808	COG3840	111	3e-26
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2809	COG3840	102	6e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2911	COG3840	76	5e-15
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2948	COG3840	81	2e-16
ABC-type thiamine transport system ATPase component	H	Contig28	Nham2970	COG3840	77	3e-15
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3026	COG3840	73	5e-14
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3048	COG3840	103	5e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3428	COG3840	110	9e-26
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3544	COG3840	121	2e-28
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3557	COG3840	181	8e-47
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3648	COG3840	101	5e-23
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3649	COG3840	76	2e-15
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3729	COG3840	118	4e-28
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3736	COG3840	116	4e-27
ABC-type thiamine transport system ATPase component	H	Contig28	Nham3991	COG3840	80	4e-16
ABC-type tungstate transport system periplasmic component	H	Contig28	Nham0434	COG4662	81	4e-17
ABC-type tungstate transport system periplasmic component	H	Contig28	Nham0637	COG4662	40	2e-04
ABC-type tungstate transport system periplasmic component	H	Contig28	Nham3558	COG4662	78	5e-16
ABC-type tungstate transport system periplasmic component	H	Contig28	Nham3559	COG4662	80	2e-16

BIOTIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham0219	COG0156	43	3e-05
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham0276	COG0156	441	1.0e-125
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham1194	COG0156	45	9e-06
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham1305	COG0156	37	0.003
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham1814	COG0156	38	0.002
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham2329	COG0156	38	0.002
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham2458	COG0156	48	1e-06
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham2676	COG0156	40	3e-04
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham2816	COG0156	355	2e-99
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham3037	COG0156	40	2e-04
7-keto-8-aminopelargonate synthetase	H	Contig28	Nham3111	COG0156	48	2e-06
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham0276	COG0161	36	0.004
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham0642	COG0161	279	2e-76
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham2676	COG0161	290	1e-79
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham2814	COG0161	487	1.0e-139
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham3111	COG0161	293	2e-80
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig28	Nham3157	COG0161	470	1.0e-134
Biotin-(acetyl-CoA carboxylase) ligase	H	Contig28	Nham2206	COG0340	182	4e-47
Biotin-(acetyl-CoA carboxylase) ligase	H	Contig28	Nham3119	COG0340	38	5e-04
Biotin synthase	H	Contig28	Nham0277	COG0502	401	1.0e-113
Biotin synthase	H	Contig28	Nham1831	COG0502	63	3e-11
Biotin synthase	H	Contig28	Nham2689	COG0502	49	6e-07
Dethiobiotin synthetase	H	Contig28	Nham2348	COG0132	34	0.008
Dethiobiotin synthetase	H	Contig28	Nham2815	COG0132	198	3e-52

COBALAMIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cobyric acid synthase	H	Contig28	Nham0124	COG1492	39	2e-04
Cobyric acid synthase	H	Contig28	Nham1635	COG1492	35	0.005
Cobyrinic acid a c-diamide synthase	H	Contig28	Nham1635	COG1797	41	1e-04
Cobyrinic acid a c-diamide synthase	H	Contig28	Nham3578	COG1797	36	0.008
Precorrin-2 methylase	H	Contig28	Nham0147	COG2243	41	1e-04
Precorrin-2 methylase	H	Contig28	Nham3562	COG2243	74	2e-14
Precorrin-3B methylase	H	Contig28	Nham3562	COG1010	71	2e-13
Precorrin-6B methylase 1	H	Contig28	Nham0147	COG2241	38	7e-04
Precorrin-6B methylase 1	H	Contig28	Nham3562	COG2241	55	1e-08
Precorrin-6B methylase 2	H	Contig25	Nham4641	COG2242	36	0.003
Precorrin-6B methylase 2	H	Contig28	Nham0049	COG2242	39	5e-04
Precorrin-6B methylase 2	H	Contig28	Nham0696	COG2242	37	0.001
Precorrin-6B methylase 2	H	Contig28	Nham1199	COG2242	35	0.007
Precorrin-6B methylase 2	H	Contig28	Nham1794	COG2242	52	3e-08
Precorrin-6B methylase 2	H	Contig28	Nham1929	COG2242	59	1e-09
Precorrin-6B methylase 2	H	Contig28	Nham2226	COG2242	40	2e-04
Precorrin-6B methylase 2	H	Contig28	Nham2368	COG2242	41	1e-04
Precorrin-6B methylase 2	H	Contig28	Nham2370	COG2242	39	3e-04
Precorrin-6B methylase 2	H	Contig28	Nham2909	COG2242	35	0.006
Precorrin-6B methylase 2	H	Contig28	Nham3142	COG2242	39	6e-04
Precorrin-6B methylase 2	H	Contig28	Nham3170	COG2242	36	0.002
Precorrin-6B methylase 2	H	Contig28	Nham3214	COG2242	38	8e-04

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5 6-dimethylbenzimidazole phosphoribosyltransferase)	H	Contig28	Nham0499	COG4547	718	0.0

COBALAMIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uroporphyrinogen-III methylase	H	Contig28	Nham0147	COG0007	45	6e-06
Uroporphyrinogen-III methylase	H	Contig28	Nham3562	COG0007	250	2e-67

COENZYME A BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dephospho-CoA kinase	H	Contig28	Nham0114	COG0237	168	2e-43
Dephospho-CoA kinase	H	Contig28	Nham0791	COG0237	45	1e-05
Ketol-acid reductoisomerase	H	Contig28	Nham0673	COG0059	37	0.002
Ketol-acid reductoisomerase	H	Contig28	Nham2720	COG0059	538	1.0e-154
Ketol-acid reductoisomerase	H	Contig28	Nham2752	COG0059	36	0.005
Ketopantoate hydroxymethyltransferase	H	Contig28	Nham1683	COG0413	344	5e-96
Ketopantoate reductase	H	Contig28	Nham0186	COG1893	223	1e-59
Ketopantoate reductase	H	Contig28	Nham0560	COG1893	53	4e-08
Ketopantoate reductase	H	Contig28	Nham1057	COG1893	43	3e-05
Ketopantoate reductase	H	Contig28	Nham2755	COG1893	39	7e-04
Ketopantoate reductase	H	Contig28	Nham3106	COG1893	35	0.009
Panthothenate kinase	H	Contig28	Nham0128	COG1072	341	3e-95
Panthothenate synthetase	H	Contig28	Nham1299	COG0414	38	0.002
Panthothenate synthetase	H	Contig28	Nham2423	COG0414	322	2e-89
Phosphopantetheine adenylyltransferase	H	Contig28	Nham1766	COG0669	193	5e-51
Phosphopantothenoylcysteine synthetase/decarboxylase	H	Contig28	Nham0051	COG0452	365	1.0e-102

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Coenzyme F390 synthetase	H	Contig28	Nham0558	COG1541	44	3e-05
Coenzyme F390 synthetase	H	Contig28	Nham0936	COG1541	99	7e-23
Coenzyme F390 synthetase	H	Contig28	Nham2005	COG1541	41	2e-04
Coenzyme F390 synthetase	H	Contig28	Nham2555	COG1541	68	1e-12
Coenzyme F390 synthetase	H	Contig28	Nham3600	COG1541	52	1e-07
Coenzyme F390 synthetase	H	Contig28	Nham3734	COG1541	48	1e-06
Coenzyme F390 synthetase	H	Contig28	Nham3748	COG1541	46	9e-06

DEOXYXYLULOSE PATHWAY OF TERPENOID BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham0778	COG1154	910	0.0
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham1749	COG1154	40	3e-04
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham1750	COG1154	92	8e-20
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham3108	COG1154	102	4e-23
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham3109	COG1154	47	2e-06
Deoxyxylulose-5-phosphate synthase	H	Contig28	Nham3531	COG1154	73	7e-14

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dihydrofolate reductase	H	Contig28	Nham2729	COG0262	143	8e-36
Dihydroneopterin aldolase	H	Contig28	Nham2634	COG1539	114	2e-27
Dihydropteroate synthase	H	Contig28	Nham2633	COG0294	246	2e-66
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1	H	Contig28	Nham0046	COG1179	96	2e-21
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1	H	Contig28	Nham1369	COG1179	69	9e-13

FAD BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
3 4-dihydroxy-2-butanone 4-phosphate synthase	H	Contig28	Nham0752	COG0108	271	6e-74
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig28	Nham2542	COG0175	39	8e-04
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig28	Nham3561	COG0175	175	3e-45
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig28	Nham3563	COG0175	154	7e-39
FAD synthase	H	Contig28	Nham3161	COG0196	306	2e-84
GTP cyclohydrolase II	H	Contig28	Nham0752	COG0807	103	3e-23
Pyrimidine deaminase	H	Contig28	Nham1816	COG0117	182	3e-47
Pyrimidine deaminase	H	Contig28	Nham3172	COG0117	76	9e-16
Pyrimidine deaminase	H	Contig28	Nham3264	COG0117	46	2e-06
Pyrimidine reductase riboflavin biosynthesis	H	Contig28	Nham1816	COG1985	187	1e-48
Riboflavin synthase alpha chain	H	Contig28	Nham1817	COG0307	206	1e-54
Riboflavin synthase beta-chain	H	Contig28	Nham1818	COG0054	144	4e-36

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham0071	COG1635	38	0.001
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham0105	COG1635	36	0.010
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham0537	COG1635	38	0.001
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham0613	COG1635	41	1e-04
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham0924	COG1635	38	0.002
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham1137	COG1635	44	2e-05
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham1240	COG1635	36	0.006
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham1329	COG1635	36	0.006
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham1533	COG1635	42	2e-04
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham1752	COG1635	37	0.004
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2047	COG1635	44	3e-05
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2320	COG1635	37	0.002
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2553	COG1635	45	1e-05
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2641	COG1635	46	4e-06
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2683	COG1635	35	0.010
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham2744	COG1635	50	4e-07
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham3218	COG1635	44	3e-05
Flavoprotein involved in thiazole biosynthesis	H	Contig28	Nham3916	COG1635	40	4e-04
Folylpolyglutamate synthase	H	Contig28	Nham0060	COG0285	370	1.0e-103
Folylpolyglutamate synthase	H	Contig28	Nham1274	COG0285	76	6e-15
Folylpolyglutamate synthase	H	Contig28	Nham1275	COG0285	39	0.001
Folylpolyglutamate synthase	H	Contig28	Nham1277	COG0285	45	1e-05
Gamma-glutamylcysteine synthetase	H	Contig28	Nham0250	COG3572	590	1.0e-170
Geranylgeranyl pyrophosphate synthase	H	Contig28	Nham0623	COG0142	208	4e-55
Geranylgeranyl pyrophosphate synthase	H	Contig28	Nham3215	COG0142	280	1e-76
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig28	Nham0145	COG0189	230	1e-61
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig28	Nham0189	COG0189	48	1e-06
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig28	Nham2165	COG0189	38	0.001
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig28	Nham2189	COG0189	54	2e-08
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig28	Nham2875	COG0189	47	8e-06
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham0056	COG2266	39	4e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham0376	COG2266	40	2e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham1059	COG2266	41	1e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham2601	COG2266	55	1e-08
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham2767	COG2266	40	2e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham3052	COG2266	39	4e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig28	Nham3133	COG2266	48	7e-07
GTP cyclohydrolase I	H	Contig28	Nham1657	COG0302	262	1e-71

HEME BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig28	Nham0021	COG0635	60	3e-10
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig28	Nham0149	COG0635	363	1.0e-101
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig28	Nham2300	COG0635	35	0.010
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig28	Nham2689	COG0635	37	0.003
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig28	Nham3574	COG0635	56	6e-09
Coproporphyrinogen III oxidase	H	Contig28	Nham3246	COG0408	402	1.0e-113
Delta-aminolevulinic acid dehydratase	H	Contig28	Nham2240	COG0113	507	1.0e-145
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham0276	COG0001	44	2e-05
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham0642	COG0001	164	7e-42
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham2676	COG0001	205	4e-54
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham2814	COG0001	156	4e-39
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham3111	COG0001	181	9e-47
Glutamate-1-semialdehyde aminotransferase	H	Contig28	Nham3157	COG0001	166	4e-42
Glutamyl-tRNA reductase	H	Contig28	Nham0045	COG0373	36	0.003
Glutamyl-tRNA reductase	H	Contig28	Nham1109	COG0373	54	9e-09
Glutamyl-tRNA reductase	H	Contig28	Nham1470	COG0373	46	3e-06
Porphobilinogen deaminase	H	Contig28	Nham0562	COG0181	343	8e-96
Protoheme ferro-lyase (ferrochelatase)	H	Contig28	Nham3415	COG0276	360	1.0e-101
Protoporphyrinogen oxidase	H	Contig28	Nham0071	COG1232	47	3e-06
Protoporphyrinogen oxidase	H	Contig28	Nham0613	COG1232	59	6e-10
Protoporphyrinogen oxidase	H	Contig28	Nham0924	COG1232	36	0.005
Protoporphyrinogen oxidase	H	Contig28	Nham0940	COG1232	36	0.002
Protoporphyrinogen oxidase	H	Contig28	Nham1021	COG1232	39	8e-04
Protoporphyrinogen oxidase	H	Contig28	Nham1137	COG1232	45	1e-05
Protoporphyrinogen oxidase	H	Contig28	Nham1240	COG1232	35	0.006
Protoporphyrinogen oxidase	H	Contig28	Nham1533	COG1232	78	2e-15
Protoporphyrinogen oxidase	H	Contig28	Nham2683	COG1232	75	1e-14
Protoporphyrinogen oxidase	H	Contig28	Nham2965	COG1232	36	0.008
Protoporphyrinogen oxidase	H	Contig28	Nham3218	COG1232	48	2e-06
Protoporphyrinogen oxidase	H	Contig28	Nham3916	COG1232	38	0.001
Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)	H	Contig28	Nham3562	COG1648	144	1e-35
Uroporphyrinogen-III decarboxylase	H	Contig28	Nham2936	COG0407	350	8e-98
Uroporphyrinogen-III synthase	H	Contig28	Nham0563	COG1587	97	1e-21
Uroporphyrinogen-III synthase	H	Contig28	Nham2963	COG1587	88	5e-19

LEUCINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	H	Contig28	Nham1840	COG0115	219	2e-58
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	H	Contig28	Nham3139	COG0115	219	3e-58
Thiamine pyrophosphate-requiring protein	H	Contig27	Nham4190	COG0028	400	1.0e-112
Thiamine pyrophosphate-requiring protein	H	Contig28	Nham2722	COG0028	651	0.0
Thiamine pyrophosphate-requiring protein	H	Contig28	Nham3384	COG0028	267	2e-72
Thiamine pyrophosphate-requiring protein	H	Contig28	Nham3531	COG0028	38	0.003

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Lipoate-protein ligase A	H	Contig28	Nham2163	COG0095	37	0.001
Lipoate-protein ligase B	H	Contig28	Nham2163	COG0321	267	6e-73
Lipoate synthase	H	Contig28	Nham0277	COG0320	43	3e-05
Lipoate synthase	H	Contig28	Nham1831	COG0320	474	1.0e-135
Membrane-associated lipoprotein involved in thiamine biosynthesis	H	Contig28	Nham3636	COG1477	266	2e-72

MENAQUINONE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
1 4-dihydroxy-2-naphthoate octaprenyltransferase	H	Contig28	Nham0257	COG1575	37	0.002
1 4-dihydroxy-2-naphthoate octaprenyltransferase	H	Contig28	Nham2292	COG1575	34	0.009
1 4-dihydroxy-2-naphthoate octaprenyltransferase	H	Contig28	Nham3461	COG1575	37	0.002
2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase	H	Contig27	Nham4190	COG1165	61	2e-10
2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase	H	Contig28	Nham2722	COG1165	79	8e-16
2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase	H	Contig28	Nham3384	COG1165	40	4e-04
Dihydroxynaphthoic acid synthase	H	Contig28	Nham0357	COG0447	56	1e-08
Dihydroxynaphthoic acid synthase	H	Contig28	Nham0781	COG0447	90	1e-19
Dihydroxynaphthoic acid synthase	H	Contig28	Nham0938	COG0447	110	1e-25
Dihydroxynaphthoic acid synthase	H	Contig28	Nham1087	COG0447	61	4e-10
Dihydroxynaphthoic acid synthase	H	Contig28	Nham2557	COG0447	47	2e-06
Dihydroxynaphthoic acid synthase	H	Contig28	Nham2662	COG0447	130	7e-32
Isochorismate synthase	H	Contig28	Nham1044	COG1169	138	2e-33
Isochorismate synthase	H	Contig28	Nham3238	COG1169	117	3e-27
O-succinylbenzoate synthase	H	Contig28	Nham1314	COG1441	39	4e-04

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Mg-chelatase subunit ChlI	H	Contig27	Nham4198	COG1239	39	0.001
Mg-chelatase subunit ChlI	H	Contig28	Nham0130	COG1239	64	1e-11
Mg-chelatase subunit ChlI	H	Contig28	Nham1839	COG1239	39	7e-04
Mg-chelatase subunit ChlI	H	Contig28	Nham3251	COG1239	58	1e-09
Mg-chelatase subunit ChlI	H	Contig28	Nham3991	COG1239	41	4e-04
Molybdenum cofactor biosynthesis enzyme	H	Contig28	Nham1732	COG0315	205	2e-54
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham0277	COG2896	37	0.002
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham0890	COG2896	59	3e-10
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham1477	COG2896	387	1.0e-109
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham2300	COG2896	37	0.002
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham2680	COG2896	74	2e-14
Molybdenum cofactor biosynthesis protein	H	Contig28	Nham3222	COG2896	38	0.001
Molybdopterin-binding protein	H	Contig28	Nham2953	COG3585	52	3e-08
Molybdopterin biosynthesis enzyme	H	Contig28	Nham1730	COG0303	344	6e-96
Molybdopterin biosynthesis enzyme	H	Contig28	Nham2591	COG0303	42	5e-05
Molybdopterin biosynthesis enzyme	H	Contig28	Nham2601	COG0303	109	4e-25
Molybdopterin biosynthesis enzyme	H	Contig28	Nham3130	COG0303	371	1.0e-104
Molybdopterin biosynthesis enzyme	H	Contig28	Nham3134	COG0303	356	4e-99
Molybdopterin biosynthesis enzyme	H	Contig28	Nham3135	COG0303	157	1e-39
Molybdopterin biosynthesis enzyme	H	Contig28	Nham3223	COG0303	56	2e-09
Molybdopterin biosynthesis protein	H	Contig28	Nham2591	COG0521	50	1e-07
Molybdopterin biosynthesis protein	H	Contig28	Nham2601	COG0521	37	0.003
Molybdopterin biosynthesis protein	H	Contig28	Nham3130	COG0521	44	1e-05
Molybdopterin biosynthesis protein	H	Contig28	Nham3223	COG0521	205	2e-54
Molybdopterin converting factor large subunit	H	Contig28	Nham3143	COG0314	152	1e-38
Molybdopterin converting factor small subunit	H	Contig28	Nham3144	COG1977	83	4e-18
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham0056	COG0746	41	1e-04
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham1059	COG0746	38	0.001
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham1201	COG0746	35	0.006
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham1784	COG0746	43	6e-05
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham2601	COG0746	74	3e-14
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham2767	COG0746	46	3e-06
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham3052	COG0746	36	0.002
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig28	Nham3133	COG0746	146	2e-36
Molybdopterin-guanine dinucleotide biosynthesis protein	H	Contig26	Nham4525	COG1763	37	0.001
Molybdopterin-guanine dinucleotide biosynthesis protein	H	Contig27	Nham4271	COG1763	38	8e-04
Molybdopterin-guanine dinucleotide biosynthesis protein	H	Contig27	Nham4281	COG1763	37	0.002
Molybdopterin-guanine dinucleotide biosynthesis protein	H	Contig28	Nham3131	COG1763	153	1e-38

NAD BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Aspartate oxidase	H	Contig28	Nham1482	COG0029	35	0.010
Aspartate oxidase	H	Contig28	Nham1752	COG0029	38	0.002
Aspartate oxidase	H	Contig28	Nham2584	COG0029	37	0.002
Aspartate oxidase	H	Contig28	Nham2820	COG0029	530	1.0e-152
Aspartate oxidase	H	Contig28	Nham3618	COG0029	352	5e-98
NAD synthase	H	Contig28	Nham0695	COG0171	36	0.004
NAD synthase	H	Contig28	Nham1485	COG0171	256	4e-69
NAD synthase	H	Contig28	Nham2542	COG0171	46	6e-06
Nicotinamide mononucleotide adenylyltransferase	H	Contig28	Nham1766	COG1056	46	1e-06
Nicotinate-nucleotide pyrophosphorylase	H	Contig28	Nham2821	COG0157	357	1.0e-100
Nicotinic acid mononucleotide adenylyltransferase	H	Contig28	Nham0521	COG1057	139	2e-34
Nicotinic acid mononucleotide adenylyltransferase	H	Contig28	Nham1766	COG1057	52	3e-08
Nicotinic acid phosphoribosyltransferase	H	Contig28	Nham3403	COG1488	291	5e-80
Quinolinate synthase	H	Contig28	Nham2819	COG0379	415	1.0e-117

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Na+/panthothenate symporter	H	Contig28	Nham0274	COG4145	47	7e-06
Outer membrane cobalamin receptor protein	H	Contig28	Nham0746	COG4206	53	9e-08
Outer membrane cobalamin receptor protein	H	Contig28	Nham0957	COG4206	55	3e-08
Outer membrane cobalamin receptor protein	H	Contig28	Nham0972	COG4206	47	4e-06
Outer membrane cobalamin receptor protein	H	Contig28	Nham1025	COG4206	69	1e-12
Outer membrane cobalamin receptor protein	H	Contig28	Nham1513	COG4206	53	1e-07
Outer membrane cobalamin receptor protein	H	Contig28	Nham2201	COG4206	66	8e-12
Outer membrane cobalamin receptor protein	H	Contig28	Nham2621	COG4206	300	2e-82
Outer membrane cobalamin receptor protein	H	Contig28	Nham3257	COG4206	59	1e-09
Outer membrane cobalamin receptor protein	H	Contig28	Nham3292	COG4206	82	2e-16
Outer membrane cobalamin receptor protein	H	Contig28	Nham3366	COG4206	118	2e-27
Outer membrane cobalamin receptor protein	H	Contig28	Nham3500	COG4206	96	1e-20
Outer membrane cobalamin receptor protein	H	Contig28	Nham3638	COG4206	74	5e-14
Outer membrane cobalamin receptor protein	H	Contig28	Nham3716	COG4206	62	9e-11
Outer membrane cobalamin receptor protein	H	Contig28	Nham3719	COG4206	39	0.001
Precorrin-4 methylase	H	Contig28	Nham0147	COG2875	36	0.003
Precorrin-4 methylase	H	Contig28	Nham3562	COG2875	142	4e-35
Predicted glutamine amidotransferase involved in pyridoxine biosynthesis	H	Contig28	Nham1635	COG0311	38	7e-04
Predicted HD superfamily hydrolase involved in NAD metabolism	H	Contig28	Nham1757	COG1713	36	0.006
Pterin-4a-carbinolamine dehydratase	H	Contig27	Nham4341	COG2154	41	2e-05
Pterin-4a-carbinolamine dehydratase	H	Contig28	Nham3629	COG2154	109	5e-26

PYRIDOXAL PHOSPHATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham0045	COG1052	323	1e-89
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham0428	COG1052	257	7e-70
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham0673	COG1052	39	4e-04
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham1119	COG1052	274	9e-75
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham2720	COG1052	36	0.003
Lactate dehydrogenase and related dehydrogenase	H	Contig28	Nham2752	COG1052	40	4e-04
Phosphoserine aminotransferase	H	Contig28	Nham1118	COG1932	366	1.0e-102
Phosphoserine aminotransferase	H	Contig28	Nham2804	COG1932	50	3e-07
Pyridoxal phosphate biosynthesis protein	H	Contig28	Nham2254	COG0854	275	3e-75
Pyridoxal phosphate biosynthesis protein	H	Contig28	Nham2344	COG1995	367	1.0e-103
Pyridoxal/pyridoxine/pyridoxamine kinase	H	Contig28	Nham0010	COG2240	40	3e-04
Pyridoxal/pyridoxine/pyridoxamine kinase	H	Contig28	Nham1310	COG2240	66	2e-12
Pyridoxamine-phosphate oxidase	H	Contig28	Nham0765	COG0259	270	5e-74
Pyridoxine biosynthesis enzyme	H	Contig28	Nham3650	COG0214	36	0.004

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyruvate decarboxylase	H	Contig27	Nham4190	COG3961	116	5e-27
Pyruvate decarboxylase	H	Contig28	Nham0542	COG3961	39	0.002
Pyruvate decarboxylase	H	Contig28	Nham2722	COG3961	181	2e-46
Pyruvate decarboxylase	H	Contig28	Nham3384	COG3961	109	4e-25
S-adenosylhomocysteine hydrolase	H	Contig28	Nham2720	COG0499	46	5e-06
S-adenosylhomocysteine hydrolase	H	Contig28	Nham2752	COG0499	615	1.0e-177
S-adenosylmethionine synthetase	H	Contig28	Nham2753	COG0192	565	1.0e-162

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	H	Contig28	Nham0046	COG0476	256	9e-70
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	H	Contig28	Nham1369	COG0476	71	2e-13
Hydroxyethylthiazole kinase sugar kinase family	H	Contig28	Nham1310	COG2145	34	0.010
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	H	Contig28	Nham1299	COG0351	37	0.003
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	H	Contig28	Nham1310	COG0351	320	5e-89
Sulfur transfer protein involved in thiamine biosynthesis	H	Contig28	Nham2892	COG2104	65	9e-13
Thiamine biosynthesis ATP pyrophosphatase	H	Contig28	Nham2542	COG0301	40	5e-04
Thiamine biosynthesis protein ThiC	H	Contig28	Nham2896	COG0422	732	0.0
Thiamine biosynthesis protein ThiH	H	Contig28	Nham0277	COG1060	66	5e-12
Thiamine biosynthesis protein ThiH	H	Contig28	Nham1477	COG1060	41	1e-04
Thiamine monophosphate kinase	H	Contig28	Nham1636	COG0611	50	5e-07
Thiamine monophosphate kinase	H	Contig28	Nham1820	COG0611	252	4e-68
Thiamine monophosphate kinase	H	Contig28	Nham2118	COG0611	50	2e-07
Thiamine monophosphate synthase	H	Contig28	Nham2894	COG0352	171	4e-44
Thiamine monophosphate synthase	H	Contig28	Nham3535	COG0352	68	7e-13

TRANSCRIPTIONAL REGULATORS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Transcriptional regulator of a riboflavin/FAD biosynthetic operon	H	Contig28	Nham0249	COG1339	34	0.007

TRYPTOPHAN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Anthranilate/para-aminobenzoate synthase component I	H	Contig28	Nham1044	COG0147	370	1.0e-103
Anthranilate/para-aminobenzoate synthase component I	H	Contig28	Nham3238	COG0147	333	2e-92
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham0124	COG0512	47	1e-06
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham1044	COG0512	220	4e-58
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham2542	COG0512	90	5e-19
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham2871	COG0512	101	8e-23
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham3238	COG0512	231	1e-61
Anthranilate/para-aminobenzoate synthase component II	H	Contig28	Nham4023	COG0512	38	6e-04

UBIQUINONE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig25	Nham4629	COG2227	38	5e-04
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig25	Nham4641	COG2227	51	1e-07
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham0049	COG2227	53	3e-08
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham0467	COG2227	36	0.003
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham0474	COG2227	270	1e-73
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham0677	COG2227	46	3e-06
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham0696	COG2227	64	1e-11
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham1199	COG2227	48	1e-06
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham2226	COG2227	55	6e-09
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham2287	COG2227	68	1e-12
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham2368	COG2227	61	2e-10
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham2746	COG2227	42	5e-05
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham3033	COG2227	40	4e-04
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig28	Nham3050	COG2227	40	2e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham0088	COG0654	245	3e-66
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham0537	COG0654	39	0.001
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham0613	COG0654	37	0.003
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham0924	COG0654	201	8e-53
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham0947	COG0654	37	0.005
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1021	COG0654	54	2e-08
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1057	COG0654	36	0.004
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1137	COG0654	45	9e-06
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1240	COG0654	37	0.002
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1321	COG0654	40	2e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1329	COG0654	35	0.009
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1535	COG0654	93	3e-20
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham1752	COG0654	40	3e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2047	COG0654	217	1e-57
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2320	COG0654	170	2e-43
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2553	COG0654	38	0.002
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2584	COG0654	165	5e-42
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2641	COG0654	84	1e-17
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2698	COG0654	38	0.001
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2744	COG0654	40	3e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham2891	COG0654	35	0.007
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham3218	COG0654	62	9e-11
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig28	Nham3916	COG0654	41	2e-04
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig27	Nham4303	COG0543	77	1e-15
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig28	Nham0682	COG0543	50	5e-07
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig28	Nham0932	COG0543	92	4e-20
3-polyprenyl-4-hydroxybenzoate decarboxylase	H	Contig28	Nham0051	COG0163	45	1e-05
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig28	Nham0257	COG0382	67	2e-12
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig28	Nham0986	COG0382	50	2e-07
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig28	Nham3184	COG0382	172	3e-44
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig28	Nham3461	COG0382	67	2e-12
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig25	Nham4629	COG2226	39	2e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig25	Nham4641	COG2226	60	3e-10
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0049	COG2226	283	7e-78
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0197	COG2226	39	6e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0467	COG2226	44	1e-05
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0469	COG2226	41	1e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0474	COG2226	44	1e-05
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0481	COG2226	38	0.001
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0677	COG2226	46	1e-06
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham0696	COG2226	92	4e-20
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham1050	COG2226	37	0.001
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham1199	COG2226	50	2e-07
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham1794	COG2226	40	1e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham1929	COG2226	37	0.005
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2226	COG2226	93	2e-20
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2287	COG2226	51	1e-07
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2368	COG2226	49	5e-07
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2543	COG2226	46	5e-06
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2746	COG2226	39	4e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2873	COG2226	39	3e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham2909	COG2226	64	8e-12
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham3029	COG2226	38	0.001
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham3050	COG2226	60	1e-10
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham3142	COG2226	44	1e-05
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig28	Nham3231	COG2226	37	0.003

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of heme biosynthesis	H	Contig28	Nham0565	COG3071	104	1e-23
Uncharacterized protein of heme biosynthesis	H	Contig28	Nham2170	COG3071	36	0.005

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