Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig28	Nham3671	COG0737	228	1e-60
Adenine deaminase	F	Contig28	Nham2283	COG1001	49	6e-07
Adenine deaminase	F	Contig28	Nham3973	COG1001	43	3e-05
Adenine deaminase	F	Contig28	Nham4018	COG1001	55	1e-08
Adenosine deaminase	F	Contig28	Nham0160	COG2169	75	6e-15
Adenosine deaminase	F	Contig28	Nham2823	COG2169	52	6e-08
Adenosine deaminase	F	Contig28	Nham2987	COG2169	41	2e-04
ADP-ribose pyrophosphatase	F	Contig28	Nham0482	COG1051	53	9e-09
ADP-ribose pyrophosphatase	F	Contig28	Nham0527	COG1051	42	3e-05
ADP-ribose pyrophosphatase	F	Contig28	Nham1987	COG1051	45	3e-06
ADP-ribose pyrophosphatase	F	Contig28	Nham3249	COG1051	38	4e-04
ADP-ribose pyrophosphatase	F	Contig28	Nham3259	COG1051	47	1e-06
ADP-ribose pyrophosphatase	F	Contig28	Nham4015	COG1051	87	7e-19
Cytosine/adenosine deaminase	F	Contig28	Nham1816	COG0590	74	2e-14
Cytosine/adenosine deaminase	F	Contig28	Nham3172	COG0590	174	3e-45
Cytosine/adenosine deaminase	F	Contig28	Nham3264	COG0590	131	4e-32
Deoxycytidylate deaminase	F	Contig28	Nham1816	COG2131	67	3e-12
Deoxycytidylate deaminase	F	Contig28	Nham3172	COG2131	53	1e-08
Deoxycytidylate deaminase	F	Contig28	Nham3264	COG2131	42	3e-05
Deoxynucleoside kinase	F	Contig28	Nham0164	COG1428	37	0.001
dGTP triphosphohydrolase	F	Contig28	Nham1757	COG0232	380	1.0e-107
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig28	Nham0461	COG0537	72	2e-14
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig28	Nham2451	COG0537	137	3e-34
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig28	Nham2807	COG0537	121	2e-29
Exopolyphosphatase	F	Contig28	Nham2114	COG0248	312	5e-86
Exopolyphosphatase	F	Contig28	Nham2550	COG0248	280	1e-76
Guanylate kinase	F	Contig28	Nham2068	COG0194	36	0.003
Guanylate kinase	F	Contig28	Nham2348	COG0194	249	1e-67
Orotate phosphoribosyltransferase homologs	F	Contig28	Nham0451	COG0856	50	2e-07
Orotate phosphoribosyltransferase homologs	F	Contig28	Nham0480	COG0856	36	0.003
Orotate phosphoribosyltransferase homologs	F	Contig28	Nham1899	COG0856	40	2e-04
Orotate phosphoribosyltransferase homologs	F	Contig28	Nham2293	COG0856	55	1e-08
Orotate phosphoribosyltransferase homologs	F	Contig28	Nham3237	COG0856	40	1e-04
Predicted nucleotide kinase	F	Contig27	Nham4051	COG1618	35	0.008
Predicted nucleotide kinase	F	Contig28	Nham1074	COG1618	43	2e-05
Predicted nucleotide kinase	F	Contig28	Nham2640	COG1618	37	0.003
Predicted nucleotide kinase	F	Contig28	Nham3012	COG1618	36	0.005
Predicted nucleotide kinase	F	Contig28	Nham3273	COG4088	36	0.001
Predicted nucleotide kinase	F	Contig28	Nham3564	COG4088	40	6e-04
Predicted nucleotide kinase	F	Contig28	Nham3749	COG1618	35	0.008

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig28	Nham2569	COG0015	518	1.0e-148
Adenylosuccinate lyase	F	Contig28	Nham2732	COG0015	98	2e-21
Adenylosuccinate lyase	F	Contig28	Nham3477	COG0015	119	3e-28
Adenylosuccinate synthase	F	Contig28	Nham1123	COG0104	631	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig28	Nham0195	COG0138	740	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig28	Nham2875	COG0138	39	0.002
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig28	Nham2119	COG0299	243	7e-66
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig28	Nham3694	COG0299	71	8e-14
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham1235	COG0027	136	3e-33
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham2124	COG0027	60	4e-10
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham2165	COG0027	49	1e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham2189	COG0027	60	5e-10
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham2875	COG0027	43	1e-04
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig28	Nham3173	COG0027	41	1e-04
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig28	Nham0480	COG0034	36	0.004
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig28	Nham2057	COG0034	131	1e-31
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig28	Nham2293	COG0034	637	0.0
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig28	Nham3237	COG0034	37	0.001
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham0124	COG0518	60	2e-10
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham1044	COG0518	80	5e-16
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham2542	COG0518	200	3e-52
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham2871	COG0518	82	5e-17
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham3238	COG0518	73	5e-14
GMP synthase - Glutamine amidotransferase domain	F	Contig28	Nham4023	COG0518	35	0.005
GMP synthase PP-ATPase domain/subunit	F	Contig28	Nham0695	COG0519	39	6e-04
GMP synthase PP-ATPase domain/subunit	F	Contig28	Nham2542	COG0519	549	1.0e-157
IMP dehydrogenase/GMP reductase	F	Contig28	Nham2546	COG0516	135	7e-33
Phosphoribosylamine-glycine ligase	F	Contig28	Nham1283	COG0151	36	0.006
Phosphoribosylamine-glycine ligase	F	Contig28	Nham2124	COG0151	53	5e-08
Phosphoribosylamine-glycine ligase	F	Contig28	Nham2165	COG0151	47	4e-06
Phosphoribosylamine-glycine ligase	F	Contig28	Nham2189	COG0151	56	8e-09
Phosphoribosylamine-glycine ligase	F	Contig28	Nham2875	COG0151	37	0.005
Phosphoribosylamine-glycine ligase	F	Contig28	Nham3173	COG0151	562	1.0e-161
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig28	Nham1636	COG0150	46	7e-06
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig28	Nham1820	COG0150	54	1e-08
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig28	Nham2118	COG0150	448	1.0e-127
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham0544	COG0026	36	0.004
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham1235	COG0026	435	1.0e-123
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham2124	COG0026	59	7e-10
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham2165	COG0026	63	7e-11
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham2189	COG0026	59	7e-10
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig28	Nham3173	COG0026	36	0.004
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig28	Nham1633	COG0152	329	1e-91
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig28	Nham1236	COG0041	209	8e-56
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig28	Nham1635	COG0047	317	5e-88
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig28	Nham2542	COG0047	41	2e-04
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	Contig28	Nham1634	COG1828	97	2e-22
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig28	Nham1636	COG0046	892	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig28	Nham1820	COG0046	48	8e-07
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig28	Nham2118	COG0046	36	0.005
Phosphoribosylpyrophosphate synthetase	F	Contig28	Nham0451	COG0462	36	0.003
Phosphoribosylpyrophosphate synthetase	F	Contig28	Nham1899	COG0462	170	1e-43
Phosphoribosylpyrophosphate synthetase	F	Contig28	Nham3091	COG0462	411	1.0e-116
Phosphoribosylpyrophosphate synthetase	F	Contig28	Nham3237	COG0462	43	1e-05

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham0451	COG0503	62	4e-11
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham0480	COG0503	37	0.001
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham1899	COG0503	43	3e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham2293	COG0503	45	2e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham2590	COG0503	84	4e-18
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham3091	COG0503	40	2e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig28	Nham3237	COG0503	177	3e-46
Formyltetrahydrofolate hydrolase	F	Contig28	Nham2119	COG0788	128	3e-31
Formyltetrahydrofolate hydrolase	F	Contig28	Nham3694	COG0788	47	2e-06
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig28	Nham0480	COG0634	41	9e-05
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig28	Nham2293	COG0634	41	2e-04
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig28	Nham2590	COG0634	42	2e-05
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig28	Nham3091	COG0634	42	7e-05
Purine nucleoside phosphorylase	F	Contig26	Nham4378	COG0005	36	0.004
Purine nucleoside phosphorylase	F	Contig26	Nham4539	COG0005	36	0.003

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig27	Nham4194	COG0563	36	0.007
Adenylate kinase and related kinase	F	Contig28	Nham0164	COG0563	48	5e-07
Adenylate kinase and related kinase	F	Contig28	Nham0402	COG0563	38	0.001
Adenylate kinase and related kinase	F	Contig28	Nham1566	COG0563	189	1e-49
Adenylate kinase and related kinase	F	Contig28	Nham3521	COG0563	36	0.005
Aspartate carbamoyltransferase catalytic chain	F	Contig28	Nham0643	COG0540	175	3e-45
Aspartate carbamoyltransferase catalytic chain	F	Contig28	Nham2282	COG0540	374	1.0e-105
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham0189	COG0458	43	3e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham1235	COG0458	43	4e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham2124	COG0458	67	5e-12
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham2165	COG0458	83	5e-17
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham2189	COG0458	78	1e-15
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham2875	COG0458	547	1.0e-156
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig28	Nham3173	COG0458	38	0.001
Carbamoylphosphate synthase small subunit	F	Contig28	Nham1044	COG0505	64	3e-11
Carbamoylphosphate synthase small subunit	F	Contig28	Nham2542	COG0505	65	1e-11
Carbamoylphosphate synthase small subunit	F	Contig28	Nham2871	COG0505	548	1.0e-157
Carbamoylphosphate synthase small subunit	F	Contig28	Nham3238	COG0505	96	6e-21
Carbamoylphosphate synthase small subunit	F	Contig28	Nham4023	COG0505	41	1e-04
CTP synthase (UTP-ammonia lyase)	F	Contig28	Nham0124	COG0504	35	0.004
CTP synthase (UTP-ammonia lyase)	F	Contig28	Nham1738	COG0504	863	0.0
CTP synthase (UTP-ammonia lyase)	F	Contig28	Nham2871	COG0504	43	4e-05
CTP synthase (UTP-ammonia lyase)	F	Contig28	Nham3238	COG0504	40	6e-04
Cytidylate kinase	F	Contig28	Nham0164	COG1102	56	2e-09
Cytidylate kinase	F	Contig28	Nham0164	COG0283	208	2e-55
Cytidylate kinase	F	Contig28	Nham0490	COG1102	41	1e-04
Cytidylate kinase	F	Contig28	Nham1566	COG0283	35	0.004
Dihydroorotase and related cyclic amidohydrolase	F	Contig28	Nham2283	COG0044	402	1.0e-113
Dihydroorotase and related cyclic amidohydrolase	F	Contig28	Nham3973	COG0044	53	3e-08
Dihydroorotase and related cyclic amidohydrolase	F	Contig28	Nham4018	COG0044	417	1.0e-117
Dihydroorotase	F	Contig28	Nham2283	COG0418	38	0.002
Dihydroorotase	F	Contig28	Nham4018	COG0418	40	3e-04
Dihydroorotate dehydrogenase	F	Contig28	Nham0555	COG0167	291	5e-80
Dihydroorotate dehydrogenase	F	Contig28	Nham1112	COG0167	39	4e-04
Dihydroorotate dehydrogenase	F	Contig28	Nham1835	COG0167	47	2e-06
Dihydroorotate dehydrogenase	F	Contig28	Nham2546	COG0167	38	0.002
Dihydroorotate dehydrogenase	F	Contig28	Nham3650	COG0167	46	3e-06
Orotate phosphoribosyltransferase	F	Contig28	Nham0451	COG0461	145	3e-36
Orotate phosphoribosyltransferase	F	Contig28	Nham0480	COG0461	36	0.003
Orotate phosphoribosyltransferase	F	Contig28	Nham1899	COG0461	37	0.001
Orotate phosphoribosyltransferase	F	Contig28	Nham3091	COG0461	39	5e-04
Orotate phosphoribosyltransferase	F	Contig28	Nham3237	COG0461	58	5e-10
Orotidine-5'-phosphate decarboxylase	F	Contig28	Nham1688	COG0284	199	1e-52
Uridylate kinase	F	Contig28	Nham0472	COG0528	70	3e-13
Uridylate kinase	F	Contig28	Nham0518	COG0528	49	4e-07
Uridylate kinase	F	Contig28	Nham1696	COG0528	294	3e-81
Uridylate kinase	F	Contig28	Nham2954	COG0528	71	1e-13
Uridylate kinase	F	Contig28	Nham2956	COG0528	66	3e-12

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytosine deaminase and related metal-dependent hydrolase	F	Contig28	Nham2283	COG0402	41	2e-04
Cytosine deaminase and related metal-dependent hydrolase	F	Contig28	Nham3973	COG0402	74	2e-14
Cytosine deaminase and related metal-dependent hydrolase	F	Contig28	Nham4018	COG0402	66	5e-12
Nucleoside phosphorylase	F	Contig26	Nham4378	COG0775	49	4e-07
Nucleoside phosphorylase	F	Contig26	Nham4539	COG0775	50	2e-07
Nucleoside phosphorylase	F	Contig28	Nham0980	COG0775	88	7e-19
Nucleoside phosphorylase	F	Contig28	Nham2681	COG0775	49	2e-07
Nucleoside phosphorylase	F	Contig28	Nham3696	COG0775	77	8e-16
Purine-nucleoside phosphorylase	F	Contig26	Nham4378	COG0813	67	2e-12
Purine-nucleoside phosphorylase	F	Contig26	Nham4539	COG0813	66	3e-12
Purine-nucleoside phosphorylase	F	Contig28	Nham0980	COG0813	63	3e-11
Thymidine phosphorylase	F	Contig28	Nham1734	COG0213	65	6e-12
Thymidine phosphorylase	F	Contig28	Nham1900	COG0213	327	1e-90
Uracil phosphoribosyltransferase	F	Contig28	Nham0451	COG0035	37	0.001
Uridine kinase	F	Contig27	Nham4047	COG0572	54	9e-09
Uridine kinase	F	Contig28	Nham0128	COG0572	70	3e-13
Uridine kinase	F	Contig28	Nham1915	COG0572	39	0.001
Uridine kinase	F	Contig28	Nham3753	COG0572	54	9e-09

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig28	Nham2893	COG2022	356	1.0e-100

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig28	Nham0052	COG0717	64	5e-12
Deoxycytidine deaminase	F	Contig28	Nham0218	COG0717	123	2e-29
dUTPase	F	Contig28	Nham0052	COG0756	179	1e-46
Nucleoside diphosphate kinase	F	Contig28	Nham2122	COG0105	194	2e-51
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig28	Nham1815	COG1328	36	0.001
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig28	Nham3663	COG1328	63	8e-11
Ribonucleotide reductase alpha subunit	F	Contig28	Nham2084	COG0209	246	1e-65
Ribonucleotide reductase alpha subunit	F	Contig28	Nham3663	COG0209	555	1.0e-159
Ribonucleotide reductase beta subunit	F	Contig28	Nham3664	COG0208	329	2e-91
Thymidylate kinase	F	Contig28	Nham0114	COG0125	37	8e-04
Thymidylate kinase	F	Contig28	Nham1566	COG0125	35	0.004
Thymidylate kinase	F	Contig28	Nham2010	COG0125	216	1e-57
Thymidylate kinase	F	Contig28	Nham2348	COG0125	37	0.001
Thymidylate synthase	F	Contig28	Nham2730	COG0207	423	1.0e-120

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uridine phosphorylase	F	Contig26	Nham4378	COG2820	86	3e-18
Uridine phosphorylase	F	Contig26	Nham4539	COG2820	84	1e-17
Uridine phosphorylase	F	Contig28	Nham0980	COG2820	83	2e-17
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham1039	COG4630	131	3e-32
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham1040	COG4630	105	7e-24
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham1182	COG4630	105	2e-24
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham1453	COG4630	119	1e-28
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham1455	COG4630	101	6e-23
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham2606	COG4630	91	7e-20
Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A	F	Contig28	Nham2607	COG4630	121	2e-29
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig28	Nham1041	COG4631	166	5e-42
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig28	Nham1181	COG4631	72	1e-13
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig28	Nham1307	COG4631	219	6e-58
Xanthine dehydrogenase molybdopterin-binding subunit B	F	Contig28	Nham1454	COG4631	241	1e-64
Xanthine/uracil permease	F	Contig28	Nham0705	COG2233	44	2e-05
Xanthine/uracil permease	F	Contig28	Nham1108	COG2233	39	8e-04
Xanthine/uracil permease	F	Contig28	Nham1878	COG2233	41	2e-04
Xanthosine triphosphate pyrophosphatase	F	Contig28	Nham0150	COG0127	207	6e-55
Xanthosine triphosphate pyrophosphatase	F	Contig28	Nham0791	COG0127	61	2e-10

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