Coenzyme Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylase	H	Contig13	Neut1127	COG0043	671	0.0
4-hydroxybenzoate synthetase (chorismate lyase)	H	Contig13	Neut1129	COG3161	93	1e-20
5 10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	H	Contig13	Neut1072	COG0190	38	8e-04
5 10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	H	Contig13	Neut1607	COG0190	385	1.0e-108
5-formyltetrahydrofolate cyclo-ligase	H	Contig13	Neut2308	COG0212	127	5e-31
6-pyruvoyl-tetrahydropterin synthase	H	Contig13	Neut1286	COG0720	100	4e-23
7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	H	Contig13	Neut2295	COG0801	184	3e-48
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0063	COG1120	98	5e-22
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0152	COG1120	107	2e-24
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0236	COG1120	158	4e-40
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0315	COG1120	93	6e-20
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0504	COG1120	143	3e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0628	COG1120	164	4e-42
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0851	COG1120	165	4e-42
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0856	COG1120	165	4e-42
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0890	COG1120	117	3e-27
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0915	COG1120	114	2e-26
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut0974	COG1120	143	1e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1009	COG1120	140	3e-34
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1024	COG1120	185	3e-48
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1240	COG1120	98	6e-22
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1328	COG1120	174	8e-45
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1342	COG1120	144	4e-36
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1397	COG1120	156	7e-39
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1516	COG1120	136	2e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1528	COG1120	127	5e-31
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1643	COG1120	117	4e-28
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1653	COG1120	115	8e-27
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1661	COG1120	137	2e-33
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1704	COG1120	154	7e-39
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1764	COG1120	129	4e-31
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut1936	COG1120	144	9e-36
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2011	COG1120	163	2e-41
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2053	COG1120	130	1e-31
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2235	COG1120	154	8e-39
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2302	COG1120	168	5e-43
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2311	COG1120	65	1e-11
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2377	COG1120	40	5e-04
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2426	COG1120	133	2e-32
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2441	COG1120	144	3e-35
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2459	COG1120	62	2e-10
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2462	COG1120	145	8e-36
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2491	COG1120	150	8e-38
ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components	H	Contig13	Neut2509	COG1120	134	6e-33
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0063	COG4138	55	3e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0152	COG4138	72	9e-14
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0236	COG4138	58	8e-10
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0315	COG4138	56	8e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0504	COG4138	53	4e-08
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0628	COG4138	64	8e-12
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0851	COG4138	74	2e-14
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0856	COG4138	78	9e-16
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0890	COG4138	56	6e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0915	COG4138	67	3e-12
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut0974	COG4138	68	4e-13
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1009	COG4138	79	1e-15
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1024	COG4138	79	8e-16
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1240	COG4138	52	3e-08
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1328	COG4138	70	2e-13
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1342	COG4138	69	2e-13
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1397	COG4138	60	6e-10
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1516	COG4138	57	1e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1528	COG4138	73	2e-14
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1643	COG4138	56	2e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1653	COG4138	61	2e-10
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1661	COG4138	68	2e-12
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1704	COG4138	78	5e-16
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1764	COG4138	63	5e-11
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut1936	COG4138	72	3e-14
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2011	COG4138	60	1e-10
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2053	COG4138	60	2e-10
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2235	COG4138	77	1e-15
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2302	COG4138	82	5e-17
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2426	COG4138	58	1e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2441	COG4138	63	9e-11
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2459	COG4138	48	3e-06
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2462	COG4138	67	5e-12
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2491	COG4138	54	8e-09
ABC-type cobalamin transport system ATPase component	H	Contig13	Neut2509	COG4138	73	2e-14
ABC-type thiamine transport system ATPase component	H	Contig12	Neut2552	COG3840	40	6e-04
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0063	COG3840	68	4e-13
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0152	COG3840	75	7e-15
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0236	COG3840	117	8e-28
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0315	COG3840	57	3e-09
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0504	COG3840	111	2e-25
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0628	COG3840	150	8e-38
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0851	COG3840	142	3e-35
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0856	COG3840	99	2e-22
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0890	COG3840	73	4e-14
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0915	COG3840	102	9e-23
ABC-type thiamine transport system ATPase component	H	Contig13	Neut0974	COG3840	119	2e-28
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1009	COG3840	100	5e-22
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1024	COG3840	173	1e-44
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1240	COG3840	66	3e-12
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1328	COG3840	183	1e-47
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1342	COG3840	126	1e-30
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1397	COG3840	125	1e-29
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1516	COG3840	128	3e-31
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1528	COG3840	113	1e-26
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1643	COG3840	90	2e-19
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1653	COG3840	88	2e-18
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1661	COG3840	109	5e-25
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1704	COG3840	127	7e-31
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1764	COG3840	133	4e-32
ABC-type thiamine transport system ATPase component	H	Contig13	Neut1936	COG3840	103	2e-23
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2011	COG3840	151	3e-38
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2053	COG3840	140	1e-34
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2235	COG3840	134	8e-33
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2302	COG3840	106	2e-24
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2311	COG3840	71	2e-13
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2426	COG3840	152	5e-38
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2441	COG3840	108	1e-24
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2459	COG3840	37	0.006
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2462	COG3840	137	2e-33
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2491	COG3840	124	4e-30
ABC-type thiamine transport system ATPase component	H	Contig13	Neut2509	COG3840	95	7e-21
ABC-type thiamine transport system periplasmic component	H	Contig13	Neut1331	COG4143	41	1e-04
ABC-type tungstate transport system periplasmic component	H	Contig13	Neut0238	COG4662	50	3e-07
ABC-type tungstate transport system periplasmic component	H	Contig13	Neut1025	COG4662	63	2e-11
ABC-type tungstate transport system periplasmic component	H	Contig13	Neut1026	COG4662	72	5e-14
ABC-type tungstate transport system periplasmic component	H	Contig13	Neut1329	COG4662	39	4e-04
ABC-type tungstate transport system periplasmic component	H	Contig13	Neut1330	COG4662	38	8e-04

BIOTIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut0424	COG0156	44	2e-05
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut0461	COG0156	345	3e-96
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut1159	COG0156	36	0.006
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut1238	COG0156	39	7e-04
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut1552	COG0156	37	0.002
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut1569	COG0156	46	6e-06
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut2067	COG0156	39	8e-04
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut2137	COG0156	395	1.0e-111
7-keto-8-aminopelargonate synthetase	H	Contig13	Neut2174	COG0156	50	3e-07
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig13	Neut0208	COG0161	497	1.0e-142
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig13	Neut1537	COG0161	174	1e-44
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig13	Neut2067	COG0161	302	4e-83
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	H	Contig13	Neut2174	COG0161	298	6e-82
Biotin-(acetyl-CoA carboxylase) ligase	H	Contig13	Neut0232	COG0340	193	1e-50
Biotin synthase	H	Contig13	Neut0757	COG0502	53	2e-08
Biotin synthase	H	Contig13	Neut2138	COG0502	390	1.0e-110
Dethiobiotin synthetase	H	Contig13	Neut2120	COG0132	41	3e-04
Dethiobiotin synthetase	H	Contig13	Neut2134	COG0132	227	4e-61
Pimeloyl-CoA synthetase	H	Contig13	Neut1102	COG1424	36	0.005

COBALAMIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
ATP:corrinoid adenosyltransferase	H	Contig13	Neut1918	COG2109	243	5e-66
Cobyric acid synthase	H	Contig13	Neut1907	COG1492	43	1e-05
Cobyric acid synthase	H	Contig13	Neut2134	COG1492	41	8e-05
Cobyrinic acid a c-diamide synthase	H	Contig13	Neut1136	COG1797	36	0.003
Cobyrinic acid a c-diamide synthase	H	Contig13	Neut2134	COG1797	51	1e-07
Precorrin-2 methylase	H	Contig13	Neut1002	COG2243	75	1e-14
Precorrin-2 methylase	H	Contig13	Neut1660	COG2243	48	1e-06
Precorrin-3B methylase	H	Contig13	Neut1002	COG1010	91	2e-19
Precorrin-3B methylase	H	Contig13	Neut1660	COG1010	48	1e-06
Precorrin-6B methylase 1	H	Contig13	Neut1002	COG2241	73	4e-14
Precorrin-6B methylase 2	H	Contig13	Neut0065	COG2242	41	1e-04
Precorrin-6B methylase 2	H	Contig13	Neut0197	COG2242	60	1e-10
Precorrin-6B methylase 2	H	Contig13	Neut0320	COG2242	39	4e-04
Precorrin-6B methylase 2	H	Contig13	Neut0322	COG2242	43	2e-05
Precorrin-6B methylase 2	H	Contig13	Neut0682	COG2242	54	1e-08
Precorrin-6B methylase 2	H	Contig13	Neut0828	COG2242	59	3e-10
Precorrin-6B methylase 2	H	Contig13	Neut1059	COG2242	41	7e-05
Precorrin-6B methylase 2	H	Contig13	Neut1898	COG2242	43	2e-05
Precorrin-6B methylase 2	H	Contig13	Neut2280	COG2242	50	2e-07
Precorrin-6B methylase 2	H	Contig13	Neut2323	COG2242	47	1e-06
Precorrin-6B methylase 2	H	Contig13	Neut2342	COG2242	44	8e-06

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5 6-dimethylbenzimidazole phosphoribosyltransferase)	H	Contig13	Neut0518	COG4547	38	0.003

COBALAMIN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uroporphyrinogen-III methylase	H	Contig13	Neut1002	COG0007	336	2e-93

COENZYME A BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dephospho-CoA kinase	H	Contig13	Neut0382	COG0237	35	0.005
Dephospho-CoA kinase	H	Contig13	Neut1045	COG0237	182	2e-47
Ketol-acid reductoisomerase	H	Contig13	Neut1260	COG0059	547	1.0e-157
Ketopantoate hydroxymethyltransferase	H	Contig13	Neut2293	COG0413	356	1e-99
Ketopantoate reductase	H	Contig13	Neut0226	COG1893	36	0.005
Ketopantoate reductase	H	Contig13	Neut0660	COG1893	38	0.001
Ketopantoate reductase	H	Contig13	Neut1093	COG1893	41	2e-04
Ketopantoate reductase	H	Contig13	Neut1568	COG1893	42	6e-05
Panthothenate synthetase	H	Contig13	Neut2292	COG0414	321	3e-89
Phosphopantetheine adenylyltransferase	H	Contig13	Neut1610	COG0669	39	4e-04
Phosphopantetheine adenylyltransferase	H	Contig13	Neut2341	COG0669	227	4e-61
Phosphopantothenoylcysteine synthetase/decarboxylase	H	Contig13	Neut0783	COG0452	380	1.0e-106
Phosphopantothenoylcysteine synthetase/decarboxylase	H	Contig13	Neut2307	COG0452	34	0.007

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Coenzyme F390 synthetase	H	Contig13	Neut0458	COG1541	48	2e-06
Coenzyme F390 synthetase	H	Contig13	Neut1097	COG1541	205	5e-54
Coenzyme F390 synthetase	H	Contig13	Neut1417	COG1541	46	7e-06
Coenzyme F390 synthetase	H	Contig13	Neut1690	COG1541	44	2e-05
Coenzyme F390 synthetase	H	Contig13	Neut2466	COG1541	45	2e-05
Cytosine/uracil/thiamine/allantoin permease	H	Contig13	Neut2160	COG1953	41	5e-04

DEOXYXYLULOSE PATHWAY OF TERPENOID BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxyxylulose-5-phosphate synthase	H	Contig13	Neut1501	COG1154	926	0.0
Deoxyxylulose-5-phosphate synthase	H	Contig13	Neut1577	COG1154	65	2e-11

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dihydrofolate reductase	H	Contig13	Neut1020	COG0262	152	2e-38
Dihydroneopterin aldolase	H	Contig13	Neut0294	COG1539	93	6e-21
Dihydropteroate synthase	H	Contig13	Neut0999	COG0294	260	1e-70
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1	H	Contig13	Neut0916	COG1179	98	5e-22

FAD BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
3 4-dihydroxy-2-butanone 4-phosphate synthase	H	Contig13	Neut2516	COG0108	289	3e-79
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig13	Neut1187	COG0175	203	1e-53
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig13	Neut1188	COG0175	185	4e-48
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	H	Contig13	Neut2251	COG0175	37	0.004
FAD synthase	H	Contig13	Neut1440	COG0196	319	1e-88
GTP cyclohydrolase II	H	Contig13	Neut2516	COG0807	118	8e-28
Pyrimidine deaminase	H	Contig13	Neut0594	COG0117	85	3e-18
Pyrimidine deaminase	H	Contig13	Neut1091	COG0117	213	2e-56
Pyrimidine reductase riboflavin biosynthesis	H	Contig13	Neut1091	COG1985	199	2e-52
Riboflavin synthase alpha chain	H	Contig13	Neut2515	COG0307	240	5e-65
Riboflavin synthase beta-chain	H	Contig13	Neut2517	COG0054	158	3e-40
riboflavin synthase	H	Contig13	Neut2517	COG1731	36	0.002

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Flavoprotein involved in thiazole biosynthesis	H	Contig13	Neut0416	COG1635	49	4e-07
Flavoprotein involved in thiazole biosynthesis	H	Contig13	Neut0526	COG1635	38	0.001
Flavoprotein involved in thiazole biosynthesis	H	Contig13	Neut1902	COG1635	41	1e-04
Flavoprotein involved in thiazole biosynthesis	H	Contig13	Neut2103	COG1635	40	6e-04
Flavoprotein involved in thiazole biosynthesis	H	Contig13	Neut2486	COG1635	41	2e-04
Folylpolyglutamate synthase	H	Contig13	Neut0245	COG0285	47	3e-06
Folylpolyglutamate synthase	H	Contig13	Neut0248	COG0285	45	1e-05
Folylpolyglutamate synthase	H	Contig13	Neut0250	COG0285	62	8e-11
Folylpolyglutamate synthase	H	Contig13	Neut0251	COG0285	57	4e-09
Folylpolyglutamate synthase	H	Contig13	Neut0651	COG0285	43	5e-05
Folylpolyglutamate synthase	H	Contig13	Neut0907	COG0285	53	5e-08
Folylpolyglutamate synthase	H	Contig13	Neut0908	COG0285	54	3e-08
Folylpolyglutamate synthase	H	Contig13	Neut1155	COG0285	401	1.0e-113
Folylpolyglutamate synthase	H	Contig13	Neut1402	COG0285	73	7e-14
Geranylgeranyl pyrophosphate synthase	H	Contig13	Neut0825	COG0142	287	1e-78
Geranylgeranyl pyrophosphate synthase	H	Contig13	Neut1500	COG0142	234	5e-63
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut0243	COG0189	53	4e-08
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut0327	COG0189	53	3e-08
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut0455	COG0189	42	2e-04
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut0904	COG0189	79	4e-16
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut0953	COG0189	222	4e-59
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut1401	COG0189	70	4e-13
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut1402	COG0189	50	9e-07
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut1899	COG0189	46	7e-06
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut2116	COG0189	59	4e-10
Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)	H	Contig13	Neut2470	COG0189	39	0.002
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut0159	COG2266	39	4e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut0268	COG2266	40	1e-04
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut0279	COG2266	42	8e-05
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut1101	COG2266	34	0.008
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut1292	COG2266	38	0.002
GTP:adenosylcobinamide-phosphate guanylyltransferase	H	Contig13	Neut1880	COG2266	44	9e-06

HEME BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig13	Neut0310	COG0635	364	1.0e-102
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig13	Neut1389	COG0635	37	0.003
Coproporphyrinogen III oxidase and related Fe-S oxidoreductase	H	Contig13	Neut1789	COG0635	51	2e-07
Coproporphyrinogen III oxidase	H	Contig13	Neut1956	COG0408	467	1.0e-133
Delta-aminolevulinic acid dehydratase	H	Contig13	Neut0235	COG0113	499	1.0e-142
Glutamate-1-semialdehyde aminotransferase	H	Contig13	Neut0208	COG0001	119	4e-28
Glutamate-1-semialdehyde aminotransferase	H	Contig13	Neut1537	COG0001	596	1.0e-171
Glutamate-1-semialdehyde aminotransferase	H	Contig13	Neut2067	COG0001	174	9e-45
Glutamate-1-semialdehyde aminotransferase	H	Contig13	Neut2137	COG0001	44	2e-05
Glutamate-1-semialdehyde aminotransferase	H	Contig13	Neut2174	COG0001	210	2e-55
Glutamyl-tRNA reductase	H	Contig13	Neut0496	COG0373	51	1e-07
Glutamyl-tRNA reductase	H	Contig13	Neut0826	COG0373	432	1.0e-122
Porphobilinogen deaminase	H	Contig13	Neut1037	COG0181	391	1.0e-110
Protoheme ferro-lyase (ferrochelatase)	H	Contig13	Neut0770	COG0276	341	5e-95
Protoporphyrinogen oxidase	H	Contig13	Neut0416	COG1232	40	4e-04
Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)	H	Contig13	Neut1002	COG1648	217	1e-57
Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)	H	Contig13	Neut1072	COG1648	36	0.003
Uroporphyrinogen-III decarboxylase	H	Contig13	Neut0603	COG0407	437	1.0e-124
Uroporphyrinogen-III synthase	H	Contig13	Neut1038	COG1587	161	5e-41

LEUCINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	H	Contig13	Neut0760	COG0115	183	1e-47
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	H	Contig13	Neut2005	COG0115	257	7e-70
Thiamine pyrophosphate-requiring protein	H	Contig13	Neut1262	COG0028	656	0.0

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Lipoate-protein ligase A	H	Contig13	Neut0758	COG0095	42	4e-05
Lipoate-protein ligase B	H	Contig13	Neut0758	COG0321	246	8e-67
Lipoate synthase	H	Contig13	Neut0757	COG0320	487	1.0e-139
Lipoate synthase	H	Contig13	Neut1389	COG0320	36	0.007
Lipoate synthase	H	Contig13	Neut2138	COG0320	43	2e-05

MENAQUINONE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
1 4-dihydroxy-2-naphthoate octaprenyltransferase	H	Contig13	Neut1128	COG1575	36	0.005
2-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylate synthase	H	Contig13	Neut1262	COG1165	51	3e-07
Dihydroxynaphthoic acid synthase	H	Contig12	Neut2550	COG0447	36	0.005
Isochorismate synthase	H	Contig13	Neut2098	COG1169	189	4e-49
shikimate kinase	H	Contig13	Neut0157	COG1685	50	3e-07

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Mg-chelatase subunit ChlD	H	Contig13	Neut0518	COG1240	44	5e-05
Mg-chelatase subunit ChlI	H	Contig13	Neut0519	COG1239	38	5e-04
Mg-chelatase subunit ChlI	H	Contig13	Neut0747	COG1239	40	5e-04
Mg-chelatase subunit ChlI	H	Contig13	Neut2377	COG1239	67	3e-12
Molybdenum cofactor biosynthesis protein	H	Contig13	Neut0292	COG2896	38	7e-04
Molybdenum cofactor biosynthesis protein	H	Contig13	Neut0310	COG2896	37	0.003
Molybdenum cofactor biosynthesis protein	H	Contig13	Neut1287	COG2896	43	2e-05
Molybdenum cofactor biosynthesis protein	H	Contig13	Neut1576	COG2896	65	7e-12
Molybdenum cofactor biosynthesis protein	H	Contig13	Neut2138	COG2896	42	7e-05
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut0159	COG0746	46	3e-06
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut0268	COG0746	38	7e-04
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut0279	COG0746	41	1e-04
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut0435	COG0746	47	1e-06
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut1880	COG0746	39	5e-04
Molybdopterin-guanine dinucleotide biosynthesis protein A	H	Contig13	Neut2374	COG0746	36	0.003
Molybdopterin-guanine dinucleotide biosynthesis protein	H	Contig13	Neut1777	COG1763	35	0.010

NAD BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Aspartate oxidase	H	Contig13	Neut1902	COG0029	43	4e-05
Aspartate oxidase	H	Contig13	Neut2004	COG0029	654	0.0
Aspartate oxidase	H	Contig13	Neut2486	COG0029	375	1.0e-105
NAD synthase	H	Contig13	Neut2008	COG0171	243	3e-65
NAD synthase	H	Contig13	Neut2251	COG0171	44	2e-05
NAD synthase	H	Contig13	Neut2336	COG0171	61	9e-11
Nicotinate-nucleotide pyrophosphorylase	H	Contig13	Neut1538	COG0157	44	9e-06
Nicotinic acid mononucleotide adenylyltransferase	H	Contig13	Neut1610	COG1057	186	1e-48
Nicotinic acid mononucleotide adenylyltransferase	H	Contig13	Neut2341	COG1057	45	3e-06
Quinolinate synthase	H	Contig13	Neut2299	COG0379	329	2e-91

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Outer membrane cobalamin receptor protein	H	Contig13	Neut0374	COG4206	58	3e-09
Outer membrane cobalamin receptor protein	H	Contig13	Neut0716	COG4206	120	3e-28
Outer membrane cobalamin receptor protein	H	Contig13	Neut0720	COG4206	50	7e-07
Outer membrane cobalamin receptor protein	H	Contig13	Neut0721	COG4206	55	2e-08
Outer membrane cobalamin receptor protein	H	Contig13	Neut1252	COG4206	102	9e-23
Outer membrane cobalamin receptor protein	H	Contig13	Neut1732	COG4206	67	3e-12
Outer membrane cobalamin receptor protein	H	Contig13	Neut1741	COG4206	50	5e-07
Outer membrane cobalamin receptor protein	H	Contig13	Neut1916	COG4206	498	1.0e-142
Outer membrane cobalamin receptor protein	H	Contig13	Neut1932	COG4206	75	2e-14
Outer membrane cobalamin receptor protein	H	Contig13	Neut1962	COG4206	61	4e-10
Outer membrane cobalamin receptor protein	H	Contig13	Neut2038	COG4206	100	5e-22
Outer membrane cobalamin receptor protein	H	Contig13	Neut2092	COG4206	75	2e-14
Precorrin-4 methylase	H	Contig13	Neut1002	COG2875	163	3e-41
Predicted glutamine amidotransferase involved in pyridoxine biosynthesis	H	Contig13	Neut1907	COG0311	36	0.002
Pterin-4a-carbinolamine dehydratase	H	Contig13	Neut0813	COG2154	44	2e-06
Pterin-4a-carbinolamine dehydratase	H	Contig13	Neut2288	COG2154	105	1e-24

PYRIDOXAL PHOSPHATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut0433	COG1052	247	1e-66
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut1260	COG1052	37	0.002
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut1304	COG1052	317	1e-87
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut1571	COG1052	173	2e-44
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut1881	COG1052	35	0.005
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut1892	COG1052	38	0.001
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut2144	COG1052	38	8e-04
Lactate dehydrogenase and related dehydrogenase	H	Contig13	Neut2243	COG1052	282	2e-77
Phosphoserine aminotransferase	H	Contig13	Neut0200	COG1932	51	2e-07
Phosphoserine aminotransferase	H	Contig13	Neut1238	COG1932	41	2e-04
Phosphoserine aminotransferase	H	Contig13	Neut1572	COG1932	491	1.0e-140
Pyridoxal phosphate biosynthesis protein	H	Contig13	Neut1218	COG1995	377	1.0e-106
Pyridoxal phosphate biosynthesis protein	H	Contig13	Neut1776	COG0854	311	4e-86
Pyridoxal/pyridoxine/pyridoxamine kinase	H	Contig13	Neut1539	COG2240	74	1e-14
Pyridoxal/pyridoxine/pyridoxamine kinase	H	Contig13	Neut1951	COG2240	36	0.003
Pyridoxine biosynthesis enzyme	H	Contig13	Neut0323	COG0214	44	8e-06

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C	H	Contig13	Neut1553	COG5424	164	6e-42
Pyruvate decarboxylase	H	Contig13	Neut1262	COG3961	164	2e-41
S-adenosylhomocysteine hydrolase	H	Contig13	Neut0212	COG0499	39	4e-04
S-adenosylhomocysteine hydrolase	H	Contig13	Neut0433	COG0499	39	4e-04
S-adenosylhomocysteine hydrolase	H	Contig13	Neut1892	COG0499	637	0.0
S-adenosylmethionine synthetase	H	Contig13	Neut1893	COG0192	662	0.0

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	H	Contig13	Neut0916	COG0476	230	1e-61
Hydroxyethylthiazole kinase sugar kinase family	H	Contig13	Neut0145	COG2145	46	6e-06
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	H	Contig13	Neut0145	COG0351	40	4e-04
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	H	Contig13	Neut1539	COG0351	247	5e-67
Sulfur transfer protein involved in thiamine biosynthesis	H	Contig13	Neut0324	COG2104	61	1e-11
Thiamine biosynthesis ATP pyrophosphatase	H	Contig13	Neut2336	COG0301	36	0.003
Thiamine biosynthesis protein ThiC	H	Contig13	Neut0196	COG0422	760	0.0
Thiamine biosynthesis protein ThiH	H	Contig13	Neut0757	COG1060	43	2e-05
Thiamine biosynthesis protein ThiH	H	Contig13	Neut2138	COG1060	54	1e-08
Thiamine monophosphate kinase	H	Contig13	Neut1654	COG0611	75	6e-15
Thiamine monophosphate kinase	H	Contig13	Neut2277	COG0611	62	5e-11
Thiamine monophosphate kinase	H	Contig13	Neut2519	COG0611	304	7e-84
Thiamine monophosphate synthase	H	Contig13	Neut0653	COG0352	137	9e-34
Thiamine monophosphate synthase	H	Contig13	Neut1538	COG0352	171	4e-44

TRANSCRIPTIONAL REGULATORS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Transcriptional regulator of a riboflavin/FAD biosynthetic operon	H	Contig13	Neut1186	COG1339	35	0.006

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Trimethylamine:corrinoid methyltransferase	H	Contig13	Neut0993	COG5598	35	0.003

TRYPTOPHAN BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Anthranilate/para-aminobenzoate synthase component I	H	Contig13	Neut2098	COG0147	506	1.0e-144
Anthranilate/para-aminobenzoate synthase component II	H	Contig13	Neut0135	COG0512	306	9e-85
Anthranilate/para-aminobenzoate synthase component II	H	Contig13	Neut0454	COG0512	94	1e-20
Anthranilate/para-aminobenzoate synthase component II	H	Contig13	Neut1032	COG0512	35	0.005
Anthranilate/para-aminobenzoate synthase component II	H	Contig13	Neut1907	COG0512	41	6e-05
Anthranilate/para-aminobenzoate synthase component II	H	Contig13	Neut2251	COG0512	75	1e-14

UBIQUINONE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0065	COG2227	67	1e-12
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0154	COG2227	53	3e-08
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0197	COG2227	40	1e-04
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0320	COG2227	60	3e-10
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0527	COG2227	36	0.002
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0682	COG2227	63	3e-11
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut0828	COG2227	36	0.003
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut1059	COG2227	66	2e-12
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut1061	COG2227	35	0.005
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut1436	COG2227	37	0.001
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut1733	COG2227	46	2e-06
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut1898	COG2227	46	3e-06
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1 4-benzoquinol methylase	H	Contig13	Neut2507	COG2227	306	1e-84
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut0416	COG0654	52	5e-08
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut0526	COG0654	44	3e-05
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut1207	COG0654	225	5e-60
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut1689	COG0654	264	8e-72
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut1770	COG0654	47	2e-06
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut1773	COG0654	37	0.004
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut1902	COG0654	42	1e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut2437	COG0654	43	6e-05
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut2486	COG0654	40	5e-04
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	H	Contig13	Neut2526	COG0654	40	4e-04
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig13	Neut0709	COG0543	85	5e-18
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig13	Neut1041	COG0543	164	1e-41
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig13	Neut1185	COG0543	45	2e-05
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase	H	Contig13	Neut1190	COG0543	83	1e-16
3-polyprenyl-4-hydroxybenzoate decarboxylase	H	Contig13	Neut0783	COG0163	50	4e-07
3-polyprenyl-4-hydroxybenzoate decarboxylase	H	Contig13	Neut2307	COG0163	241	4e-65
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig13	Neut1128	COG0382	175	3e-45
4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	H	Contig13	Neut2389	COG0382	85	8e-18
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0065	COG2226	106	1e-24
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0154	COG2226	56	6e-09
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0197	COG2226	45	4e-06
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0320	COG2226	71	2e-13
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0390	COG2226	44	3e-05
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0527	COG2226	47	8e-07
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0593	COG2226	45	6e-06
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0682	COG2226	103	2e-23
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0828	COG2226	54	1e-08
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut0838	COG2226	42	1e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut1059	COG2226	115	4e-27
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut1061	COG2226	36	0.002
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut1436	COG2226	273	9e-75
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut1733	COG2226	54	1e-08
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut1898	COG2226	41	1e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut2135	COG2226	71	1e-13
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut2280	COG2226	39	5e-04
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut2323	COG2226	43	2e-05
Methylase involved in ubiquinone/menaquinone biosynthesis	H	Contig13	Neut2507	COG2226	71	7e-14

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Ubiquinone biosynthesis protein COQ7	H	Contig13	Neut0447	COG2941	199	2e-52
Uncharacterized protein of heme biosynthesis	H	Contig13	Neut1039	COG2959	117	9e-28
Uncharacterized protein of heme biosynthesis	H	Contig13	Neut1040	COG3071	191	1e-49
Uncharacterized protein of heme biosynthesis	H	Contig13	Neut2072	COG3071	55	2e-08

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