Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine deaminase	F	Contig13	Neut0452	COG1001	46	4e-06
Adenine deaminase	F	Contig13	Neut1692	COG1001	49	8e-07
Adenine deaminase	F	Contig13	Neut1722	COG1001	37	0.003
Adenosine deaminase	F	Contig13	Neut1221	COG2169	134	1e-32
Adenosine deaminase	F	Contig13	Neut1346	COG2169	70	2e-13
Adenosine deaminase	F	Contig13	Neut2182	COG1816	41	1e-04
ADP-ribose pyrophosphatase	F	Contig13	Neut0259	COG1051	53	1e-08
ADP-ribose pyrophosphatase	F	Contig13	Neut0615	COG1051	49	1e-07
ADP-ribose pyrophosphatase	F	Contig13	Neut0653	COG1051	58	7e-10
ADP-ribose pyrophosphatase	F	Contig13	Neut1248	COG1051	48	4e-07
ADP-ribose pyrophosphatase	F	Contig13	Neut1448	COG1051	107	4e-25
Cytosine/adenosine deaminase	F	Contig13	Neut0187	COG0590	87	6e-19
Cytosine/adenosine deaminase	F	Contig13	Neut0594	COG0590	182	1e-47
Cytosine/adenosine deaminase	F	Contig13	Neut1091	COG0590	72	9e-14
Cytosine/adenosine deaminase	F	Contig13	Neut1711	COG0590	88	3e-19
Cytosine/uracil/thiamine/allantoin permease	F	Contig13	Neut2160	COG1953	41	5e-04
Deoxycytidylate deaminase	F	Contig13	Neut0594	COG2131	55	3e-09
Deoxycytidylate deaminase	F	Contig13	Neut1091	COG2131	67	2e-12
Deoxynucleoside kinase	F	Contig13	Neut2294	COG1428	152	2e-38
dGTP triphosphohydrolase	F	Contig13	Neut0380	COG0232	346	1e-96
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig13	Neut0267	COG0537	55	2e-09
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig13	Neut1912	COG0537	110	3e-26
Exopolyphosphatase	F	Contig13	Neut1831	COG0248	396	1.0e-111
Guanylate kinase	F	Contig13	Neut0614	COG0194	228	2e-61
Orotate phosphoribosyltransferase homologs	F	Contig13	Neut0262	COG0856	50	7e-08
Orotate phosphoribosyltransferase homologs	F	Contig13	Neut1140	COG0856	41	1e-04
Orotate phosphoribosyltransferase homologs	F	Contig13	Neut1158	COG0856	48	2e-06
Orotate phosphoribosyltransferase homologs	F	Contig13	Neut2050	COG0856	50	1e-07
Orotate phosphoribosyltransferase homologs	F	Contig13	Neut2139	COG0856	38	6e-04
Predicted nucleotide kinase	F	Contig13	Neut0164	COG4088	42	1e-04
Predicted nucleotide kinase	F	Contig13	Neut2294	COG4088	39	3e-04

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig13	Neut0410	COG0015	360	1.0e-100
Adenylosuccinate lyase	F	Contig13	Neut1269	COG0015	130	3e-31
Adenylosuccinate lyase	F	Contig13	Neut2124	COG0015	107	2e-24
Adenylosuccinate synthase	F	Contig13	Neut0967	COG0104	643	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig13	Neut0455	COG0138	43	1e-04
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig13	Neut1210	COG0138	750	0.0
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig13	Neut0391	COG0299	83	2e-17
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig13	Neut2278	COG0299	262	2e-71
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut0243	COG0027	45	6e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut0455	COG0027	53	1e-07
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut0904	COG0027	37	0.002
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut1201	COG0027	153	2e-38
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut1401	COG0027	40	8e-04
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig13	Neut1899	COG0027	48	1e-06
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Neut0280	COG0034	138	1e-33
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Neut0901	COG0034	73	8e-14
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Neut1158	COG0034	609	1.0e-175
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Neut1735	COG0034	47	5e-06
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig13	Neut2139	COG0034	39	2e-04
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Neut0135	COG0518	83	1e-17
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Neut0454	COG0518	80	2e-16
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Neut1032	COG0518	142	2e-35
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Neut1907	COG0518	57	9e-10
GMP synthase - Glutamine amidotransferase domain	F	Contig13	Neut2251	COG0518	210	2e-55
GMP synthase PP-ATPase domain/subunit	F	Contig13	Neut1096	COG0519	35	0.010
GMP synthase PP-ATPase domain/subunit	F	Contig13	Neut2251	COG0519	535	1.0e-153
GMP synthase PP-ATPase domain/subunit	F	Contig13	Neut2336	COG0519	40	4e-04
IMP dehydrogenase/GMP reductase	F	Contig13	Neut2250	COG0516	139	4e-34
Phosphoribosylamine-glycine ligase	F	Contig13	Neut0220	COG0151	36	0.006
Phosphoribosylamine-glycine ligase	F	Contig13	Neut0455	COG0151	47	6e-06
Phosphoribosylamine-glycine ligase	F	Contig13	Neut0606	COG0151	36	0.006
Phosphoribosylamine-glycine ligase	F	Contig13	Neut1211	COG0151	566	1.0e-162
Phosphoribosylamine-glycine ligase	F	Contig13	Neut1401	COG0151	52	2e-07
Phosphoribosylamine-glycine ligase	F	Contig13	Neut1402	COG0151	45	2e-05
Phosphoribosylamine-glycine ligase	F	Contig13	Neut1899	COG0151	57	2e-09
Phosphoribosylamine-glycine ligase	F	Contig13	Neut2116	COG0151	42	7e-05
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig13	Neut2277	COG0150	478	1.0e-136
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig13	Neut2519	COG0150	38	9e-04
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut0243	COG0026	41	1e-04
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut0455	COG0026	54	7e-08
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut0904	COG0026	51	1e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut1201	COG0026	435	1.0e-123
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut1401	COG0026	52	2e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut1402	COG0026	44	5e-05
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut1571	COG0026	36	0.005
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut1899	COG0026	64	2e-11
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig13	Neut2116	COG0026	37	0.002
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig13	Neut1200	COG0152	229	2e-61
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	F	Contig13	Neut1202	COG0041	214	2e-57
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig13	Neut0140	COG0047	254	2e-68
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig13	Neut0140	COG0046	713	0.0
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig13	Neut2277	COG0046	35	0.007
Phosphoribosylpyrophosphate synthetase	F	Contig13	Neut0262	COG0462	37	8e-04
Phosphoribosylpyrophosphate synthetase	F	Contig13	Neut0737	COG0462	34	0.006
Phosphoribosylpyrophosphate synthetase	F	Contig13	Neut1140	COG0462	404	1.0e-114
Phosphoribosylpyrophosphate synthetase	F	Contig13	Neut1158	COG0462	38	0.002
Phosphoribosylpyrophosphate synthetase	F	Contig13	Neut2139	COG0462	35	0.004

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut0262	COG0503	182	2e-47
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut0450	COG0503	34	0.008
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut1140	COG0503	37	0.001
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut1158	COG0503	43	5e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut2050	COG0503	42	5e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig13	Neut2139	COG0503	36	0.003
Formyltetrahydrofolate hydrolase	F	Contig13	Neut0391	COG0788	49	4e-07
Formyltetrahydrofolate hydrolase	F	Contig13	Neut2278	COG0788	139	1e-34
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Neut0262	COG0634	35	0.002
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Neut0450	COG0634	47	6e-07
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Neut0737	COG0634	36	0.002
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Neut1140	COG0634	38	0.001
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig13	Neut2139	COG0634	36	0.003
Purine nucleoside phosphorylase	F	Contig13	Neut0945	COG0005	202	3e-53
Purine nucleoside phosphorylase	F	Contig13	Neut1886	COG0005	41	7e-05

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig13	Neut0382	COG0563	35	0.005
Adenylate kinase and related kinase	F	Contig13	Neut0399	COG0563	38	7e-04
Adenylate kinase and related kinase	F	Contig13	Neut1704	COG0563	34	0.010
Aspartate carbamoyltransferase catalytic chain	F	Contig13	Neut0451	COG0540	354	6e-99
Aspartate carbamoyltransferase catalytic chain	F	Contig13	Neut2066	COG0540	158	3e-40
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut0243	COG0458	48	1e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut0455	COG0458	575	1.0e-165
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut0904	COG0458	58	1e-09
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut1201	COG0458	46	4e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut1211	COG0458	42	1e-04
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut1401	COG0458	58	2e-09
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut1402	COG0458	46	9e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut1899	COG0458	74	2e-14
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig13	Neut2470	COG0458	52	2e-07
Carbamoylphosphate synthase small subunit	F	Contig13	Neut0135	COG0505	89	2e-19
Carbamoylphosphate synthase small subunit	F	Contig13	Neut0454	COG0505	535	1.0e-153
Carbamoylphosphate synthase small subunit	F	Contig13	Neut1032	COG0505	41	7e-05
Carbamoylphosphate synthase small subunit	F	Contig13	Neut1907	COG0505	40	2e-04
Carbamoylphosphate synthase small subunit	F	Contig13	Neut2251	COG0505	53	7e-08
CTP synthase (UTP-ammonia lyase)	F	Contig13	Neut0454	COG0504	39	5e-04
CTP synthase (UTP-ammonia lyase)	F	Contig13	Neut1907	COG0504	34	0.008
CTP synthase (UTP-ammonia lyase)	F	Contig13	Neut2483	COG0504	870	0.0
Cytidylate kinase	F	Contig13	Neut0399	COG1102	48	6e-07
Cytidylate kinase	F	Contig13	Neut0399	COG0283	234	5e-63
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Neut0452	COG0044	375	1.0e-105
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Neut1659	COG0044	57	2e-09
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Neut1692	COG0044	55	1e-08
Dihydroorotase and related cyclic amidohydrolase	F	Contig13	Neut1722	COG0044	50	2e-07
Dihydroorotase	F	Contig13	Neut1659	COG0418	519	1.0e-148
Dihydroorotate dehydrogenase	F	Contig13	Neut0372	COG0167	46	6e-06
Dihydroorotate dehydrogenase	F	Contig13	Neut0646	COG0167	303	1e-83
Dihydroorotate dehydrogenase	F	Contig13	Neut1208	COG0167	57	2e-09
Dihydroorotate dehydrogenase	F	Contig13	Neut2250	COG0167	38	0.002
Orotate phosphoribosyltransferase	F	Contig13	Neut0262	COG0461	58	5e-10
Orotate phosphoribosyltransferase	F	Contig13	Neut0450	COG0461	39	1e-04
Orotate phosphoribosyltransferase	F	Contig13	Neut1140	COG0461	38	0.001
Orotate phosphoribosyltransferase	F	Contig13	Neut2050	COG0461	172	2e-44
Orotate phosphoribosyltransferase	F	Contig13	Neut2139	COG0461	36	0.002
Orotidine-5'-phosphate decarboxylase	F	Contig13	Neut0402	COG0284	234	5e-63
Uridylate kinase	F	Contig13	Neut0958	COG0528	61	1e-10
Uridylate kinase	F	Contig13	Neut2033	COG0528	297	6e-82
Uridylate kinase	F	Contig13	Neut2084	COG0528	58	1e-09

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig13	Neut0450	COG2065	152	1e-38
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig13	Neut0737	COG2065	34	0.010

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Neut0452	COG0402	44	1e-05
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Neut1692	COG0402	54	2e-08
Cytosine deaminase and related metal-dependent hydrolase	F	Contig13	Neut1722	COG0402	190	2e-49
Nucleoside phosphorylase	F	Contig13	Neut1506	COG0775	63	1e-11
Nucleoside phosphorylase	F	Contig13	Neut1886	COG0775	145	4e-36
Purine-nucleoside phosphorylase	F	Contig13	Neut0945	COG0813	36	0.003
Purine-nucleoside phosphorylase	F	Contig13	Neut1506	COG0813	42	5e-05
Purine-nucleoside phosphorylase	F	Contig13	Neut1886	COG0813	54	9e-09
Thymidine phosphorylase	F	Contig13	Neut0134	COG0213	52	7e-08
Uracil phosphoribosyltransferase	F	Contig13	Neut0262	COG0035	36	0.002
Uracil phosphoribosyltransferase	F	Contig13	Neut0450	COG0035	38	3e-04
Uracil phosphoribosyltransferase	F	Contig13	Neut1140	COG0035	36	0.004
Uridine kinase	F	Contig13	Neut0772	COG0572	51	1e-07
Uridine kinase	F	Contig13	Neut0851	COG0572	35	0.007

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig13	Neut0323	COG2022	355	2e-99

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig13	Neut0784	COG0717	46	8e-07
Deoxycytidine deaminase	F	Contig13	Neut1923	COG0717	215	2e-57
dUTPase	F	Contig13	Neut0784	COG0756	173	4e-45
Nucleoside diphosphate kinase	F	Contig13	Neut2172	COG0105	198	1e-52
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig13	Neut2467	COG1328	57	5e-09
Ribonucleotide reductase alpha subunit	F	Contig13	Neut2467	COG0209	583	1.0e-167
Ribonucleotide reductase beta subunit	F	Contig13	Neut2468	COG0208	348	4e-97
Thymidylate kinase	F	Contig13	Neut0164	COG0125	37	0.003
Thymidylate kinase	F	Contig13	Neut0536	COG0125	221	3e-59
Thymidylate kinase	F	Contig13	Neut1529	COG0125	35	0.009
Thymidylate kinase	F	Contig13	Neut2294	COG0125	63	2e-11
Thymidylate synthase	F	Contig13	Neut1021	COG0207	401	1.0e-113

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uridine phosphorylase	F	Contig13	Neut1886	COG2820	59	3e-10
Xanthine/uracil permease	F	Contig13	Neut0352	COG2233	51	3e-07
Xanthosine triphosphate pyrophosphatase	F	Contig13	Neut0309	COG0127	226	1e-60

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