Nucleotide Transport and Metabolism

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig616	1006	COG0737	43	3e-05
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig654	2292	COG0737	213	2e-56
5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase	F	Contig658	2656	COG0737	35	0.008
Adenine deaminase	F	Contig504	59	COG1001	37	0.003
Adenine deaminase	F	Contig606	840	COG1001	48	1e-06
Adenine deaminase	F	Contig635	1394	COG1001	49	5e-07
Adenine deaminase	F	Contig652	2071	COG1001	647	0.0
Adenine deaminase	F	Contig654	2275	COG1001	46	4e-06
Adenosine deaminase	F	Contig501	51	COG2169	59	3e-10
Adenosine deaminase	F	Contig547	227	COG2169	64	3e-12
Adenosine deaminase	F	Contig615	991	COG2169	58	6e-10
Adenosine deaminase	F	Contig633	1347	COG2169	51	1e-07
Adenosine deaminase	F	Contig633	1348	COG2169	70	3e-13
Adenosine deaminase	F	Contig634	1362	COG2169	77	4e-15
Adenosine deaminase	F	Contig638	1482	COG2169	61	1e-10
Adenosine deaminase	F	Contig643	1657	COG2169	65	4e-12
Adenosine deaminase	F	Contig651	2044	COG2169	76	3e-15
Adenosine deaminase	F	Contig657	2531	COG2169	70	3e-13
Adenosine deaminase	F	Contig657	2547	COG2169	65	2e-11
Adenosine deaminase	F	Contig657	2559	COG2169	45	1e-05
ADP-ribose pyrophosphatase	F	Contig600	762	COG1051	106	2e-24
ADP-ribose pyrophosphatase	F	Contig644	1702	COG1051	97	6e-22
ADP-ribose pyrophosphatase	F	Contig650	1919	COG1051	39	2e-04
ADP-ribose pyrophosphatase	F	Contig651	2000	COG1051	47	1e-06
Cytosine/adenosine deaminase	F	Contig601	783	COG0590	52	3e-08
Cytosine/adenosine deaminase	F	Contig654	2291	COG0590	181	2e-47
Deoxycytidylate deaminase	F	Contig601	783	COG2131	172	1e-44
Deoxycytidylate deaminase	F	Contig654	2291	COG2131	48	3e-07
Deoxynucleoside kinase	F	Contig626	1187	COG1428	219	1e-58
Deoxynucleoside kinase	F	Contig652	2087	COG1428	217	6e-58
Deoxyribose-phosphate aldolase	F	Contig602	796	COG0274	283	7e-78
dGTP triphosphohydrolase	F	Contig574	450	COG0232	36	0.008
Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase	F	Contig652	2076	COG0537	147	3e-37
Guanylate kinase	F	Contig524	112	COG0194	35	0.010
Guanylate kinase	F	Contig584	555	COG0194	116	8e-28
Guanylate kinase	F	Contig642	1593	COG0194	260	6e-71
Guanylate kinase	F	Contig652	2096	COG0194	35	0.006
Inosine-uridine nucleoside N-ribohydrolase	F	Contig550	239	COG1957	284	9e-78
Nucleoside 2-deoxyribosyltransferase	F	Contig621	1102	COG3613	57	1e-09
Nucleoside 2-deoxyribosyltransferase	F	Contig626	1188	COG3613	89	1e-19
Nucleoside permease	F	Contig584	554	COG1972	358	1.0e-100
Orotate phosphoribosyltransferase homologs	F	Contig606	837	COG0856	43	1e-05
Orotate phosphoribosyltransferase homologs	F	Contig606	846	COG0856	49	3e-07
Orotate phosphoribosyltransferase homologs	F	Contig634	1368	COG0856	46	5e-06
Orotate phosphoribosyltransferase homologs	F	Contig642	1584	COG0856	38	7e-04
Orotate phosphoribosyltransferase homologs	F	Contig642	1586	COG0856	36	0.004
Orotate phosphoribosyltransferase homologs	F	Contig642	1619	COG0856	35	0.004
Orotate phosphoribosyltransferase homologs	F	Contig651	1993	COG0856	48	1e-06
Predicted nucleotide kinase (related to CMP and AMP kinase)	F	Contig615	994	COG1936	41	5e-05
Predicted secreted endonuclease distantly related to Holliday junction resolvase	F	Contig588	596	COG4741	33	0.010
Protein involved in ribonucleotide reduction	F	Contig647	1833	COG1780	111	2e-26

PURINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylosuccinate lyase	F	Contig634	1373	COG0015	559	1.0e-160
Adenylosuccinate synthase	F	Contig622	1118	COG0104	685	0.0
AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	F	Contig634	1365	COG0138	759	0.0
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig634	1366	COG0299	253	5e-69
Folate-dependent phosphoribosylglycinamide formyltransferase PurN	F	Contig642	1597	COG0299	76	2e-15
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig586	577	COG0027	41	9e-05
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig601	774	COG0027	51	5e-07
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig606	842	COG0027	53	8e-08
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig634	1364	COG0027	46	3e-06
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig634	1374	COG0027	158	5e-40
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	F	Contig637	1444	COG0027	50	5e-07
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig627	1199	COG0034	78	3e-15
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig634	1368	COG0034	682	0.0
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig636	1422	COG0034	136	5e-33
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig642	1586	COG0034	36	0.006
Glutamine phosphoribosylpyrophosphate amidotransferase	F	Contig651	1993	COG0034	37	0.001
GMP synthase - Glutamine amidotransferase domain	F	Contig606	841	COG0518	69	6e-13
GMP synthase - Glutamine amidotransferase domain	F	Contig611	923	COG0518	223	2e-59
GMP synthase - Glutamine amidotransferase domain	F	Contig625	1163	COG0518	224	1e-59
GMP synthase - Glutamine amidotransferase domain	F	Contig634	1370	COG0518	38	6e-04
GMP synthase - Glutamine amidotransferase domain	F	Contig647	1779	COG0518	38	0.002
GMP synthase - Glutamine amidotransferase domain	F	Contig650	1935	COG0518	57	9e-10
GMP synthase PP-ATPase domain/subunit	F	Contig611	923	COG0519	556	1.0e-159
GMP synthase PP-ATPase domain/subunit	F	Contig625	1163	COG0519	560	1.0e-160
GMP synthase PP-ATPase domain/subunit	F	Contig651	1988	COG0519	42	8e-05
IMP dehydrogenase/GMP reductase	F	Contig623	1131	COG0516	144	2e-35
IMP dehydrogenase/GMP reductase	F	Contig634	1356	COG0516	105	6e-24
Phosphoribosylamine-glycine ligase	F	Contig601	774	COG0151	60	1e-09
Phosphoribosylamine-glycine ligase	F	Contig606	842	COG0151	71	6e-13
Phosphoribosylamine-glycine ligase	F	Contig631	1288	COG0151	45	2e-05
Phosphoribosylamine-glycine ligase	F	Contig634	1364	COG0151	515	1.0e-147
Phosphoribosylamine-glycine ligase	F	Contig634	1374	COG0151	41	2e-04
Phosphoribosylamine-glycine ligase	F	Contig637	1444	COG0151	50	3e-07
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig634	1367	COG0150	468	1.0e-133
Phosphoribosylaminoimidazole (AIR) synthetase	F	Contig634	1369	COG0150	54	3e-08
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig586	577	COG0026	57	3e-09
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig601	774	COG0026	60	8e-10
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig606	842	COG0026	53	1e-07
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig634	1364	COG0026	43	4e-05
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig634	1374	COG0026	453	1.0e-129
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	F	Contig637	1444	COG0026	63	4e-11
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase	F	Contig634	1372	COG0152	303	7e-84
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig634	1370	COG0047	321	2e-89
Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain	F	Contig647	1779	COG0047	41	2e-04
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component	F	Contig634	1371	COG1828	88	9e-20
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig634	1367	COG0046	49	6e-07
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain	F	Contig634	1369	COG0046	924	0.0
Phosphoribosylpyrophosphate synthetase	F	Contig606	837	COG0462	42	2e-05
Phosphoribosylpyrophosphate synthetase	F	Contig606	846	COG0462	46	2e-06
Phosphoribosylpyrophosphate synthetase	F	Contig634	1368	COG0462	46	6e-06
Phosphoribosylpyrophosphate synthetase	F	Contig642	1586	COG0462	449	1.0e-127
Phosphoribosylpyrophosphate synthetase	F	Contig642	1619	COG0462	50	1e-07
Phosphoribosylpyrophosphate synthetase	F	Contig651	1993	COG0462	393	1.0e-111

PURINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig606	837	COG0503	36	0.001
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig606	846	COG0503	68	3e-13
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig634	1368	COG0503	43	3e-05
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig642	1584	COG0503	132	3e-32
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig642	1586	COG0503	41	1e-04
Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein	F	Contig651	1993	COG0503	38	9e-04
Formyltetrahydrofolate hydrolase	F	Contig634	1366	COG0788	112	1e-26
Formyltetrahydrofolate hydrolase	F	Contig642	1597	COG0788	54	1e-08
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig606	837	COG0634	60	1e-10
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig634	1368	COG0634	38	0.002
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig642	1586	COG0634	40	2e-04
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig642	1619	COG0634	258	2e-70
Hypoxanthine-guanine phosphoribosyltransferase	F	Contig651	1993	COG0634	40	3e-04
Purine nucleoside phosphorylase	F	Contig602	789	COG0005	266	1e-72
Purine nucleoside phosphorylase	F	Contig651	1998	COG0005	36	0.003

PYRIMIDINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Adenylate kinase and related kinase	F	Contig578	477	COG0563	41	7e-05
Adenylate kinase and related kinase	F	Contig595	690	COG0563	192	2e-50
Adenylate kinase and related kinase	F	Contig599	744	COG0563	79	2e-16
Aspartate carbamoyltransferase catalytic chain	F	Contig606	839	COG0540	368	1.0e-103
Aspartate carbamoyltransferase catalytic chain	F	Contig607	857	COG0540	151	6e-38
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig516	86	COG0458	46	4e-06
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig586	577	COG0458	40	3e-04
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig601	774	COG0458	94	6e-20
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig606	842	COG0458	570	1.0e-163
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig634	1364	COG0458	44	2e-05
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig634	1374	COG0458	51	1e-07
Carbamoylphosphate synthase large subunit (split gene in MJ)	F	Contig637	1444	COG0458	78	2e-15
Carbamoylphosphate synthase small subunit	F	Contig606	841	COG0505	547	1.0e-157
Carbamoylphosphate synthase small subunit	F	Contig611	923	COG0505	72	1e-13
Carbamoylphosphate synthase small subunit	F	Contig625	1163	COG0505	69	7e-13
Carbamoylphosphate synthase small subunit	F	Contig647	1779	COG0505	37	0.004
CTP synthase (UTP-ammonia lyase)	F	Contig634	1370	COG0504	37	0.001
CTP synthase (UTP-ammonia lyase)	F	Contig647	1779	COG0504	914	0.0
CTP synthase (UTP-ammonia lyase)	F	Contig650	1935	COG0504	40	2e-04
Cytidylate kinase	F	Contig578	477	COG1102	54	1e-08
Cytidylate kinase	F	Contig578	477	COG0283	262	1e-71
Cytidylate kinase	F	Contig595	690	COG1102	41	7e-05
Cytidylate kinase	F	Contig595	690	COG0283	36	0.003
Cytidylate kinase	F	Contig599	744	COG1102	36	0.002
Cytidylate kinase	F	Contig658	2706	COG1102	36	0.004
Dihydroorotase and related cyclic amidohydrolase	F	Contig504	59	COG0044	36	0.003
Dihydroorotase and related cyclic amidohydrolase	F	Contig606	840	COG0044	454	1.0e-129
Dihydroorotase and related cyclic amidohydrolase	F	Contig635	1394	COG0044	70	3e-13
Dihydroorotase and related cyclic amidohydrolase	F	Contig639	1504	COG0044	39	8e-04
Dihydroorotase and related cyclic amidohydrolase	F	Contig652	2071	COG0044	47	4e-06
Dihydroorotase and related cyclic amidohydrolase	F	Contig654	2275	COG0044	57	3e-09
Dihydroorotase	F	Contig606	840	COG0418	48	1e-06
Dihydroorotate dehydrogenase	F	Contig498	41	COG0167	59	3e-10
Dihydroorotate dehydrogenase	F	Contig510	68	COG0167	48	8e-07
Dihydroorotate dehydrogenase	F	Contig584	562	COG0167	295	3e-81
Dihydroorotate dehydrogenase	F	Contig602	796	COG0167	44	6e-06
Dihydroorotate dehydrogenase	F	Contig606	844	COG0167	299	2e-82
Dihydroorotate dehydrogenase	F	Contig634	1356	COG0167	41	1e-04
Dihydroorotate dehydrogenase	F	Contig644	1689	COG0167	37	0.003
Dihydroorotate dehydrogenase	F	Contig650	1955	COG0167	43	5e-05
Orotate phosphoribosyltransferase	F	Contig606	837	COG0461	37	0.001
Orotate phosphoribosyltransferase	F	Contig606	846	COG0461	186	1e-48
Orotate phosphoribosyltransferase	F	Contig634	1368	COG0461	38	0.002
Orotate phosphoribosyltransferase	F	Contig642	1584	COG0461	48	7e-07
Orotate phosphoribosyltransferase	F	Contig642	1586	COG0461	45	6e-06
Orotate phosphoribosyltransferase	F	Contig651	1993	COG0461	42	7e-05
Orotidine-5'-phosphate decarboxylase	F	Contig605	833	COG0284	61	4e-11
Orotidine-5'-phosphate decarboxylase	F	Contig606	845	COG0284	235	1e-63
Orotidine-5'-phosphate decarboxylase	F	Contig642	1602	COG0284	41	7e-05
Uridylate kinase	F	Contig643	1638	COG0528	38	8e-04

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig606	837	COG2065	233	6e-63
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig642	1586	COG2065	35	0.007
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig642	1619	COG2065	52	2e-08
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	F	Contig651	1993	COG2065	36	0.003

PYRIMIDINE SALVAGE

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Cytidine deaminase	F	Contig602	795	COG0295	169	6e-44
Cytosine deaminase and related metal-dependent hydrolase	F	Contig504	59	COG0402	43	4e-05
Cytosine deaminase and related metal-dependent hydrolase	F	Contig606	840	COG0402	59	7e-10
Cytosine deaminase and related metal-dependent hydrolase	F	Contig635	1394	COG0402	49	5e-07
Cytosine deaminase and related metal-dependent hydrolase	F	Contig639	1504	COG0402	47	3e-06
Cytosine deaminase and related metal-dependent hydrolase	F	Contig652	2071	COG0402	50	5e-07
Cytosine deaminase and related metal-dependent hydrolase	F	Contig654	2275	COG0402	60	3e-10
Nucleoside phosphorylase	F	Contig602	788	COG0775	65	6e-12
Nucleoside phosphorylase	F	Contig602	789	COG0775	36	0.002
Nucleoside phosphorylase	F	Contig651	1998	COG0775	214	4e-57
Purine-nucleoside phosphorylase	F	Contig602	788	COG0813	348	2e-97
Purine-nucleoside phosphorylase	F	Contig602	789	COG0813	38	7e-04
Purine-nucleoside phosphorylase	F	Contig651	1998	COG0813	70	1e-13
Thymidine kinase	F	Contig532	136	COG1435	243	7e-66
Thymidine kinase	F	Contig632	1313	COG1435	223	5e-60
Thymidine phosphorylase	F	Contig602	797	COG0213	559	1.0e-160
Uracil phosphoribosyltransferase	F	Contig606	837	COG0035	46	2e-06
Uridine kinase	F	Contig551	249	COG0572	273	8e-75
Uridine kinase	F	Contig611	922	COG0572	70	2e-13

THIAMINE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uncharacterized protein of thiazole biosynthesis	F	Contig634	1356	COG2022	38	0.001

THYMIDYLATE BIOSYNTHESIS

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Deoxycytidine deaminase	F	Contig643	1637	COG0717	35	0.002
dUTPase	F	Contig643	1637	COG0756	124	3e-30
Nucleoside diphosphate kinase	F	Contig626	1180	COG0105	173	6e-45
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig621	1090	COG1328	34	0.006
Oxygen-sensitive ribonucleoside-triphosphate reductase	F	Contig628	1221	COG1328	853	0.0
Ribonucleotide reductase alpha subunit	F	Contig636	1405	COG0209	584	1.0e-168
Ribonucleotide reductase beta subunit	F	Contig636	1404	COG0208	323	1e-89
Thymidylate kinase	F	Contig626	1187	COG0125	41	5e-05
Thymidylate kinase	F	Contig652	2087	COG0125	46	3e-06
Thymidylate synthase	F	Contig596	705	COG0207	371	1.0e-104

COG Name	Group	Contig	Gene	COG ID	Score	Evalue
Uridine phosphorylase	F	Contig602	788	COG2820	156	2e-39
Uridine phosphorylase	F	Contig651	1998	COG2820	57	9e-10
Xanthine/uracil permease	F	Contig580	522	COG2233	43	4e-05
Xanthine/uracil permease	F	Contig606	838	COG2233	324	5e-90
Xanthine/uracil permease	F	Contig644	1696	COG2233	42	1e-04
Xanthosine triphosphate pyrophosphatase	F	Contig617	1011	COG0127	249	3e-67

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